Tuberculosis (TB)

Guest Editors:

  • Qian Gao (Shanghai Medical College, Fudan University, China)
  • Wenhong Zhang (Huashan Hospital, China)

tbEMI Special Topic-TB will focus on the characterization of TB which remains an unacceptable burden of human suffering and loss, overwhelmingly borne by poor and vulnerable people living in low- or middle-income countries. Progress in global TB control is, however, constrained by the lack of highly effective and widely accessible diagnostics, drugs and vaccines. EMI Special Topic-TB welcomes research reports and high quality reviews on the following areas of TB research: epidemiology, fundamental research, development of new diagnostics and biomarkers, development of new drugs and vaccines, and public health issues related to this important pathogen.

More articles to be added soon.


Title: Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β

Authors: Mishra BB, Rathinam VA, Martens GW, Martinot AJ, Kornfeld H, Fitzgerald KA, Sassetti CM

Nat Immunol 2013 Jan;14(1):52-60. doi: 10.1038/ni.2474. LINK


Title: The Role of Biomedical Research in Global Tuberculosis Control- Gaps and Challenges. A Perspective from the US

Authors: Christine F Sizemore, Amanda C Schleif, Jessica B Bernstein and Carole A Heilman

Emerg Microbes Infect 1: e9; doi:10.1038/emi.2012.21 LINK

Title: “ZS-MDR-TB” versus “ZR-MDR-TB”: Improving Treatment of MDR-TB by Identifying Pyrazinamide Susceptibility

Authors: Ying Zhang, Kwok Chiu Chang, Chi-Chiu Leung, Wing Wai Yew, Brigitte Gicquel, Dorothy Fallows, Gilla Kaplan, Richard E Chaisson and Wenhong Zhang

Emerg Microbes Infect 1: e5; doi:10.1038/emi.2012.18 LINK

Title: Tuberculosis Vaccine Research in China

Authors: Douglas B Lowrie

Emerg Microbes Infect 1: e7; doi:10.1038/emi.2012.3 LINK

Title: Global tuberculosis control: lessons learnt and future prospects

Authors: Lienhardt C, Glaziou P, Uplekar M, Lönnroth K, Getahun H, Raviglione M

Nat Rev Microbiol 2012 May 14;10(6):407-16. doi: 10.1038/nrmicro2797. LINK


Title: The challenge of new drug discovery for tuberculosis

Authors: Koul A, Arnoult E, Lounis N, Guillemont J, Andries K

Nature 2011 Jan 27;469(7331):483-90. doi: 10.1038/nature09657. LINK

Title: Towards a point-of-care test for active tuberculosis: obstacles and opportunities

Authors: McNerney R, Daley P

Nat Rev Microbiol 2011 Mar;9(3):204-13. doi: 10.1038/nrmicro2521. LINK

Title: The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ

Authors: Ma F, Xu S, Liu X, Zhang Q, Xu X, Liu M, Hua M, Li N, Yao H, Cao X

Nat Immunol 2011 Jul 24;12(9):861-9. doi: 10.1038/ni.2073. LINK

Title: A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

Authors: Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, Porcelli SA, Jacobs WR Jr

Nat Med 2011 Sep 4;17(10):1261-8. doi: 10.1038/nm.2420. LINK

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