TABLE OF CONTENT 2018

CORRESPONDENCE

1 Genetics, pathogenicity and transmissibility of novel reassortant H5N6 highly pathogenic avian influenza viruses first isolated from migratory birds in western China - Shaoxia Lu, Zongzheng Zhao, Jiajie Zhang, Weidong Wang, Xin He, Mengqi Yu, Chunmao Zhang, Xiang Li, Zhendong Guo, Xiaoyu Yang, Lina Liu, Min Zhi, Tian Fu, Xinru Lv, Wenge Ma, Mengying Liao, Hongliang Chai, Linna Liu, Jun Qian & Jianzhang Ma

2 A single residue in the αB helix of the E protein is critical for Zika virus thermostability - Dong-Yang Xie, Zhong-Yu Liu, Qing-Gong Nian, Ling Zhu, Nan Wang, Yong-Qiang Deng, Hui Zhao, Xue Ji, Xiao-Feng Li, Xiangxi Wang, Pei-Yong Shi & Cheng-Feng Qin

3 Candida blankii: an emergent opportunistic yeast with reduced susceptibility to antifungals - João Nobrega de Almeida Jr, Silvia V. Campos, Danilo Y. Thomaz, Luciana Thomaz, Renato K. G. de Almeida, Gilda M. B. Del Negro, Viviane F. Gimenes, Rafaella C. Grenfell, Adriana L. Motta, Flávia Rossi & Gil Benard

4 New insights into chikungunya virus emergence and spread from Southeast Asia - Alyssa T. Pyke, Peter R. Moore & Jamie McMahon

5 Detection of novel astroviruses MLB1 and MLB2 in the sera of febrile Tanzanian children - Samuel Cordey, Mary-Anne Hartley, Kristina Keitel, Florian Laubscher, Francisco Brito, Thomas Junier, Frank Kagoro, Josephine Samaka, John Masimba, Zamzam Said, Hosiana Temba, Tarsis Mlaganile, Mylène Docquier, Jacques Fellay, Laurent Kaiser & Valérie D’Acremont

6 Detection of Hantaviruses and Arenaviruzses in three-toed jerboas from the Inner Mongolia Autonomous Region, China - Zhiqiang Wu, Jiang Du, Liang Lu, Li Yang, Jie Dong, Lilian Sun, Yafang Zhu, Qiyong Liu & Qi Jin

7 Biodiversity of rodent anelloviruses in China - Jiang Du, Yuhui Li, Liang Lu, Dandan Zheng, Bo Liu, Li Yang, Haoxiang Su, Jie Dong, Lilian Sun, Yafang Zhu, Jian Yang, Fan Yang, Xiaobing Zhang, Qiyong Liu, Zhiqiang Wu & Qi Jin

8 Identification of tell-tale patterns in the 3′non-coding region of hantaviruses that distinguish HCPS-causing hantaviruses from HFRS-causing hantaviruses - Sathish Sankar, Jayanta Borkakoti, Mageshbabu Ramamurthy, Balaji Nandagopal, Perumal Vivekanandan & Sridharan Gopalan

9 Novel bovine hepacivirus in dairy cattle, China - Gang Lu, Kun Jia, Xiaokun Ping, Ji Huang, Aijian Luo, Peixin Wu & Shoujun Li

10 Potential transferability of mcr-3 via IS26-mediated homologous recombination in Escherichia coli - Zheng Wang, Yulin Fu, Xiang-Dang Du, Haiyang Jiang & Yang Wang

11 Re-emergence of Lloviu virus in Miniopterus schreibersii bats, Hungary, 2016 - Gábor Kemenesi, Kornélia Kurucz, Bianka Dallos, Brigitta Zana, Fanni Földes, Sándor Boldogh, Tamás Görföl, Miles W Carroll & Ferenc Jakab

12 Avian hepatitis E virus infection of duck, goose, and rabbit in northwest China - Baoyuan Liu, Mengnan Fan, Beibei Zhang, Yiyang Chen, Yani Sun, Taofeng Du, Yuchen Nan, En-Min Zhou & Qin Zhao

13 Human testicular organoid system as a novel tool to study Zika virus pathogenesis - Daniel P. Strange, Nima Pourhabibi Zarandi, Goral Trivedi, Anthony Atala, Colin E. Bishop, Hooman Sadri-Ardekani & Saguna Verma

14 A “sandwich” strategy for functional cure of chronic hepatitis B - Xuan-Yi Wang & Yu-Mei Wen

15 The emergence of novel sparrow deltacoronaviruses in the United States more closely related to porcine deltacoronaviruses than sparrow deltacoronavirus HKU17 - Qi Chen, Leyi Wang, Chenghuai Yang, Ying Zheng, Phillip C. Gauger, Tavis Anderson, Karen M. Harmon, Jianqiang Zhang, Kyoung-Jin Yoon, Rodger G. Main & Ganwu Li

16 Characterization of a novel reassortant H5N6 highly pathogenic avian influenza virus clade 2.3.4.4 in Korea, 2017 - Eun-Kyoung Lee, Yu-Na Lee, Soo-Jeong Kye, Nicola S. Lewis, Ian H. Brown, Mingeun Sagong, Gyeong-Beom Heo, Yong-Myung Kang, Hyun-Kyu Cho, Hyun-mi Kang, Sun-Ha Cheon, Myeongheon Lee, Bong-Kyun Park, Yong-Joo Kim & Youn-Jeong Lee

17 Human coronavirus OC43 outbreak in wild chimpanzees, Côte d´Ivoire, 2016 - Livia V. Patrono, Liran Samuni, Victor M. Corman, Leila Nourifar, Caroline Röthemeier, Roman M. Wittig, Christian Drosten, Sébastien Calvignac-Spencer & Fabian H. Leendertz

18 Isolation of a Yersinia enterocolitica biotype 1B strain in France, and evaluation of its genetic relatedness to other European and North American biotype 1B strains - Cyril Savin, Anne-Sophie Le Guern, Matthieu Lefranc, Sylvie Brémont, Elisabeth Carniel & Javier Pizarro-Cerdá

19 The emergence and spread of one Coxsackievirus A16 Genogroup D novel recombinant strain that caused a clustering HFMD outbreak in Shanghai, China, 2016 - Jiayu Wang, Zheng Teng, Wei Chu, Fanghao Fang, Xiaoqing Cui, Xiaokui Guo, Xi Zhang, Bruce R. Thorley & Yongzhang Zhu

20 Long-term clinical outcomes of Zika-associated Guillain-Barré syndrome - Aileen Y. Chang, Rebecca Lynch, Karen Martins, Liliana Encinales, Andrés Á. Cadena Bonfanti, Nelly Pacheco, St. Patrick Reid, Osvaldo E. Lara Sarabia, Henry J. González Torres, Stella Mejia Castillo, Onaldo Barrios Taborda, Magda Alarcon Gomez, Brenda Guerra Duran, Victor Martinez Giraldo, Angélica Benitez Ospino, Alexandra Porras, Alejandro R. Mendoza, Grace Mantus, Guangzhao Li, Jin Peng, Priyanka Kamalapathy, Lil G. Avendaño Echavez, Kimberly A. Dowd, Monica Rengifo-Pardo, Pedro Pablo Barraza, Dennys Jiménez Hernàndez, Andrés González Coba, Katya De La Hoz Mendoza, Jeffrey M. Bethony & Gary L. Simon

21 Comments on “Rolling epidemic of Legionnaires’ disease outbreaks in small geographic areas” - Sharon K. Greene, Robert Fitzhenry & Bruce Gutelius

22 Author Response to Comments on “Rolling epidemic of Legionnaires’ disease outbreaks in small geographic areas” - C. Raina MacIntyre, Amalie Dyda, Chau Minh Bui & Abrar Ahmad Chughtai

23 Nonhuman primates across sub-Saharan Africa are infected with the yaws bacterium Treponema pallidum subsp. pertenue - Sascha Knauf, Jan F. Gogarten, Verena J. Schuenemann, Hélène M. De Nys, Ariane Düx, Michal Strouhal, Lenka Mikalová, Kirsten I. Bos, Roy Armstrong, Emmanuel K. Batamuzi, Idrissa S. Chuma, Bernard Davoust, Georges Diatta, Robert D. Fyumagwa, Reuben R. Kazwala, Julius D. Keyyu, Inyasi A. V. Lejora, Anthony Levasseur, Hsi Liu, Michael A. Mayhew, Oleg Mediannikov, Didier Raoult, Roman M. Wittig, Christian Roos, Fabian H. Leendertz, David Šmajs, Kay Nieselt, Johannes Krause & Sébastien Calvignac-Spencer

24 Emergence of Morganella morganii subsp. morganii in dairy calves, China - Gen Li, Xudong Niu, Shiyu Yuan, Lu Liang, Yongxia Liu, Liping Hu, Jianzhu Liu & Ziqiang Cheng

25 A novel human coronavirus OC43 genotype detected in mainland China - Yun Zhu, Changchong Li, Li Chen, Baoping Xu, Yunlian Zhou, Ling Cao, Yunxiao Shang, Zhou Fu, Aihuan Chen, Li Deng, Yixiao Bao, Yun Sun, Limin Ning, Chunyan Liu, Ju Yin, Zhengde Xie & Kunling Shen

26 Emergence of a novel recombinant Seneca Valley virus in Central China, 2018 - Zeng Wang, Xiaozhan Zhang, Ruoqian Yan, Panpan Yang, Yanyang Wu, Dongdong Yang, Chuanzhou Bian & Jun Zhao

27 The DEVD motif of Crimean-Congo hemorrhagic fever virus nucleoprotein is essential for viral replication in tick cells - Cristiano Salata, Vanessa Monteil, Helen Karlberg, Michele Celestino, Stephanie Devignot, Mikael Leijon, Lesley Bell-Sakyi, Éric Bergeron, Friedemann Weber & Ali Mirazimi

28 Detection of distinct MERS-Coronavirus strains in dromedary camels from Kenya, 2017 - Stella Kiambi, Victor M. Corman, Rina Sitawa, Jane Githinji, James Ngoci, Abdullahi S. Ozomata, Emma Gardner, Sophie von Dobschuetz, Subhash Morzaria, Joshua Kimutai, Simon Schroeder, Obadiah Njagi, Piers Simpkin, Gabriel Rugalema, Zelalem Tadesse, Juan Lubroth, Yilma Makonnen, Christian Drosten, Marcel A. Müller & Folorunso O. Fasina

29 A novel genotype of “Anaplasma capra” in wildlife and its phylogenetic relationship with the human genotypes - Jifei Yang, Zhijie Liu, Qingli Niu, Muhammad Uzair Mukhtar, Guiquan Guan, Guangyuan Liu, Jianxun Luo & Hong Yin

30 Active sero-survey for European bat lyssavirus type-1 circulation in North African insectivorous bats - Jordi Serra-Cobo, Marc López-Roig, Rachel Lavenir, Elbia Abdelatif, Wahida Boucekkine, Mehdi Elharrak, Bachir Harif, Sehhar El Ayachi, Akram Ahmed Salama, Mohamed A. Nayel, Ahmed Elsify, Sameh G. El Rashedy, Paola De Benedictis, Franco Mutinelli, Barbara Zecchin, Dino Scaravelli, Chokri Balhoul, Ahmed Zaghawa, Hany Youssef Hassan, Ahmed Hamed Zaghloul & Hervé Bourhy

REVIEWS

31 Advances in the diagnosis and treatment of Clostridium difficile infections - Zhong Peng, Lifen Ling, Charles W. Stratton, Chunhui Li, Christopher R. Polage, Bin Wu & Yi-Wei Tang

32 Acinetobacter: an emerging pathogen with a versatile secretome - Noha M. Elhosseiny & Ahmed S. Attia

33 Yellow fever in the diagnostics laboratory - Cristina Domingo, Rémi N. Charrel, Jonas Schmidt-Chanasit, Hervé Zeller & Chantal Reusken

34 Bona fide receptor for hepatitis B and D viral infections: Mechanism, research models and molecular drug targets - Yueran Yu, Shangda Li & Weifeng Liang

35 An update on the human and animal enteric pathogen Clostridium perfringens - Raymond Kiu & Lindsay J. Hall

36 A systematic review of evidence that enteroviruses may be zoonotic - Jane K. Fieldhouse, Xinye Wang, Kerry A. Mallinson, Rick W. Tsao & Gregory C. Gray

37 Mayaro: an emerging viral threat? - Yeny Acosta-Ampudia, Diana M. Monsalve, Yhojan Rodríguez, Yovana Pacheco, Juan-Manuel Anaya & Carolina Ramírez-Santana

38 Global initiative for congenital toxoplasmosis: an observational and international comparative clinical analysis - Kamal El Bissati, Pauline Levigne, Joseph Lykins, El Bachir Adlaoui, Amina Barkat, Amina Berraho, Majda Laboudi, Bouchra El Mansouri, Azeddine Ibrahimi, Mohamed Rhajaoui, Fred Quinn, Manoradhan Murugesan, Fouad Seghrouchni, Jorge Enrique Gómez-Marín, François Peyron & Rima McLeod

39 The disparate effects of bacteriophages on antibiotic-resistant bacteria - Clara Torres-Barceló

40 Dengue virus and the host innate immune response - Naoko Uno & Ted M. Ross

41 Life cycle and morphogenesis of the hepatitis E virus - Kiyoshi Himmelsbach, Daniela Bender & Eberhard Hildt

COMMENT

42 Tackling imported tropical diseases in China - Xiao-Nong Zhou, Men-Bao Qian, Gerardo Priotto, José Ramón Franco & Jia-Gang Guo

NEWS & VIEWS

43 Companion diagnostics: new opportunities for safe and effective anti-infectious disease therapies - Yong-Jie Zhou, Guanghua Wang & Yi-Wei Tang

ORIGINAL ARTICLES

44 Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population - Rui Zhu, Tong Cheng, Zhichao Yin, Dongxiao Liu, Longfa Xu, Yongchao Li, Wei Wang, Jian Liu, Yuqiong Que, Xiangzhong Ye, Qiyi Tang, Qinjian Zhao, Shengxiang Ge, Shuizhen He & Ningshao Xia

45 Enterovirus D68 virus-like particles expressed in Pichia pastoris potently induce neutralizing antibody responses and confer protection against lethal viral infection in mice - Chao Zhang, Xueyang Zhang, Wei Zhang, Wenlong Dai, Jing Xie, Liping Ye, Hongli Wang, Huan Chen, Qingwei Liu, Sitang Gong, Lanlan Geng & Zhong Huang

46 Clinical study of tuberculosis in the head and neck region—11 years’ experience and a review of the literature - Pai Pang, Weiyi Duan, Shuchun Liu, Shuang Bai, Yanan Ma, Ruiwu Li, Fayu Liu & Changfu Sun

47 Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway - Yazhou Lin, Yucheng Jiao, Ye Yuan, Zezhu Zhou, Yuehuan Zheng, Jiaqi Xiao, Changwei Li, Zhe Chen & Peng Cao

48 Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses - Wanbo Tai, Lei He, Yufei Wang, Shihun Sun, Guangyu Zhao, Chuming Luo, Pei Li, Haiyan Zhao, Daved H. Fremont, Fang Li, Shibo Jiang, Yusen Zhou & Lanying Du

49 Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012–2016 - Jiayu Wang, Zheng Teng, Xiaoqing Cui, Chongshan Li, Hao Pan, Yaxu Zheng, Shenghua Mao, Yuying Yang, Limeng Wu, Xiaokui Guo, Xi Zhang & Yongzhang Zhu

50 Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens - Ashrafali M. Ismail, Tiange Cui, Kalpana Dommaraju, Gurdeep Singh, Shoaleh Dehghan, Jason Seto, Susmita Shrivastava, Nadia B. Fedorova, Neha Gupta, Timothy B. Stockwell, Rebecca Halpin, Ramana Madupu, Albert Heim, Adriana E. Kajon, Eric G. Romanowski, Regis P. Kowalski, Jambulingam Malathi, Kuzhanthai L. Therese, Hajib Narahari Madhavan, Qiwei Zhang, Leonardo J. Ferreyra, Morris S. Jones, Jaya Rajaiya, David W. Dyer, James Chodosh & Donald Seto

51 Broad and long-lasting immune protection against various Chikungunya genotypes demonstrated by participants in a cross-sectional study in a Cambodian rural community - Heidi Auerswald, Camille Boussioux, Saraden In, Sokthearom Mao, Sivuth Ong, Rekol Huy, Rithea Leang, Malen Chan, Veasna Duong, Sowath Ly, Arnaud Tarantola & Philippe Dussart

52 Origin and dispersal of Hepatitis E virus - Diego Forni, Rachele Cagliani, Mario Clerici & Manuela Sironi

53 Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016 - Liping Ma, Tao Jin, Hanzhong Wang, Haizhou Liu, Runkun Wang, Yong Li, Guoxiang Yang, Yanping Xiong, Jing Chen, Jun Zhang, Guang Chen, Wei Li, Di Liu, Peng Lin, Yueying Huang, George F. Gao & Quanjiao Chen

54 Use of ELISpot assay to study HBs-specific B cell responses in vaccinated and HBV infected humans - Chen Tian, Yuxin Chen, Yong Liu, Shixia Wang, Yang Li, Guiyang Wang, Juan Xia, Xiang-an Zhao, Rui Huang, Shan Lu & Chao Wu

55 Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017 - Houshun Zhu, Andrew C. Y. Lee, Can Li, Winger W. N. Mak, Yetta Y. Chen, Kwok-Hung Chan, Anna J. X. Zhang, Wai-Fong Fung, Rui-Qi Zhang, Yim-Fong Fung, Rosana W. S. Poon, Joy-Yan Lam, Sidney Tam, Ivan F. N. Hung, Honglin Chen, Kwok-Yung Yuen & Kelvin K. W. To

56 Comparison of the virulence and transmissibility of canine H3N2 influenza viruses and characterization of their canine adaptation factors - In-Won Lee, Young-Il Kim, Gyo-Jin Lim, Hyeok-Il Kwon, Young-Jae Si, Su-Jin Park, Eun-Ha Kim, Se Mi Kim, Hiep Dinh Nguyen, Min-Suk Song & Young-Ki Choi

57 Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin - Patrick C. Y. Woo, Susanna K. P. Lau, Yixin Chen, Emily Y. M. Wong, Kwok-Hung Chan, Honglin Chen, Libiao Zhang, Ningshao Xia & Kwok-Yung Yuen

58 Age-specific seroprevalence of human polyomavirus 12 and Saint Louis and New Jersey polyomaviruses - Pauline Gaboriaud, Marion Ferté, Françoise Arnold, Valérie Leblond, Jérôme Nicol, Heloïse Debare, Mélanie Le Meur, Fernanda Martini, Mauro Tognon & Antoine Touzé

59 Targeting intracellular signaling as an antiviral strategy: aerosolized LASAG for the treatment of influenza in hospitalized patients - Gerhard Scheuch, Sebastian Canisius, Karlheinz Nocker, Thomas Hofmann, Rolf Naumann, Stephan Pleschka, Stephan Ludwig, Tobias Welte & Oliver Planz

60 A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi - Ana Carreras-González, Nicolás Navasa, Itziar Martín-Ruiz, José Luis Lavín, Mikel Azkargorta, Estíbaliz Atondo, Diego Barriales, Nuria Macías-Cámara, Miguel Angel Pascual-Itoiz, Leticia Sampedro, Julen Tomás-Cortázar, Ainize Peña-Cearra, Aize Pellón, Rafael Prados-Rosales, Leticia Abecia, Félix Elortza, Ana M. Aransay, Héctor Rodríguez & Juan Anguita

61 Marmota himalayana in the Qinghai–Tibetan plateau as a special host for bi-segmented and unsegmented picobirnaviruses - Xue-lian Luo, Shan Lu, Dong Jin, Jing Yang, Shu-sheng Wu & Jianguo Xu

62 Comparison of the pathogenic potential of highly pathogenic avian influenza (HPAI) H5N6, and H5N8 viruses isolated in South Korea during the 2016–2017 winter season - Hyeok-il Kwon, Eun-Ha Kim, Young-il Kim, Su-Jin Park, Young-Jae Si, In-Won Lee, Hiep Dinh Nguyen, Kwang Min Yu, Min-Ah Yu, Ju Hwan Jung, Won-Suk Choi, Jin Jung Kwon, Su Jeong Ahn, Yun Hee Baek, Dam Van Lai, Ok-Jun Lee, Si-Wook Kim, Min-Suk Song, Sun-Woo Yoon, Chul-Joong Kim, Richard J. Webby, In-Pil Mo & Young Ki Choi

63 Integrated analysis of human-animal-vector surveillance: West Nile virus infections in Austria, 2015–2016 - Jolanta Kolodziejek, Christof Jungbauer, Stephan W. Aberle, Franz Allerberger, Zoltán Bagó, Jeremy V. Camp, Katharina Dimmel, Phebe de Heus, Michael Kolodziejek, Peter Schiefer, Bernhard Seidel, Karin Stiasny & Norbert Nowotny

64 Rapid rise of the ESBL and mcr-1 genes in Escherichia coli of chicken origin in China, 2008–2014 - Congming Wu, Yingchao Wang, Xiaomin Shi, Shuang Wang, Hongwei Ren, Zhangqi Shen, Yang Wang, Juchun Lin & Shaolin Wang

65 A four-year survey (2011–2014) of West Nile virus infection in humans, mosquitoes and birds, including the 2012 meningoencephalitis outbreak in Tunisia - Abir Monastiri, Badereddine Mechri, Ana Vázquez-González, Meriadeg Ar Gouilh, Mohamed Chakroun, Chawki Loussaief, Maha Mastouri, Najet Dimassi, Lamjed Boughzala, Mahjoub Aouni & Jordi Serra-Cobo

66 Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries - Ruiqiang Xie, Xiaohua Douglas Zhang, Qi Zhao, Bo Peng & Jun Zheng

67 Human transbodies that interfere with the functions of Ebola virus VP35 protein in genome replication and transcription and innate immune antagonism - Watee Seesuay, Surasak Jittavisutthikul, Nawannaporn Sae-lim, Nitat Sookrung, Yuwaporn Sakolvaree & Wanpen Chaicumpa

68 SuPReMe: a rapid reverse genetics method to generate clonal populations of recombinant RNA viruses - Jean-Sélim Driouich, Souand Mohamed Ali, Abdennour Amroun, Fabien Aubry, Xavier de Lamballerie & Antoine Nougairède

69 Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor - Elise Sofie Hovingh, Rob Mariman, Luis Solans, Daniëlle Hijdra, Hendrik-Jan Hamstra, Ilse Jongerius, Marjolein van Gent, Frits Mooi, Camille Locht & Elena Pinelli

70 Epidemiological surveillance of hand, foot and mouth disease in Shanghai in 2014–2016, prior to the introduction of the enterovirus 71 vaccine - Jingjing Li, Hao Pan, Xiangshi Wang, Qirong Zhu, Yanling Ge, Jiehao Cai, Yuefang Li, Aimei Xia, Jiayu Hu & Mei Zeng

71 Rolling epidemic of Legionnaires’ disease outbreaks in small geographic areas - C. Raina MacIntyre, Amalie Dyda, Chau Minh Bui & Abrar Ahmad Chughtai

72 Lysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis - Hua Yang, Wei Sha, Zhonghua Liu, Tianqi Tang, Haipeng Liu, Lianhua Qin, Zhenling Cui, Jianxia Chen, Feng Liu, Ruijuan Zheng, Xiaochen Huang, Jie Wang, Yonghong Feng & Baoxue Ge

73 Determining the effect of different environmental conditions on Ebola virus viability in clinically relevant specimens - Bernadett Palyi, Nora Magyar, Judit Henczko, Balint Szalai, Agnes Farkas, Thomas Strecker, Maria Takacs & Zoltan Kis

74 Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses - Lei Wen, Hin Chu, Bosco Ho-Yin Wong, Dong Wang, Cun Li, Xiaoyu Zhao, Man-Chun Chiu, Shuofeng Yuan, Yanhui Fan, Honglin Chen, Jie Zhou & Kwok-Yung Yuen

75 Detection of Coccidioides posadasii from xerophytic environments in Venezuela reveals risk of naturally acquired coccidioidomycosis infections - Primavera Alvarado, Marcus de Melo Teixeira, Lela Andrews, Alexis Fernandez, Gerardo Santander, Adina Doyle, Magaly Perez, Francisco Yegres & Bridget Marie Barker

76 Identification and characterization of a novel rodent bocavirus from different rodent species in China - Chi Zhang, Fenglin Song, Leshan Xiu, Yang Liu, Jian Yang, Lisi Yao & Junping Peng

77 Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris - Johanna Rhodes, Alireza Abdolrasouli, Rhys A. Farrer, Christina A. Cuomo, David M. Aanensen, Darius Armstrong-James, Matthew C. Fisher & Silke Schelenz

78 Wild birds in Chile Harbor diverse avian influenza A viruses - Pedro Jiménez-Bluhm, Erik A. Karlsson, Pamela Freiden, Bridgett Sharp, Francisca Di Pillo, Jorge E. Osorio, Christopher Hamilton-West & Stacey Schultz-Cherry

79 Phylogenetic analysis and virulence determinant of the host-adapted Staphylococcus aureus lineage ST188 in China - Yanan Wang, Qingyun Liu, Qian Liu, Qianqian Gao, Huiying Lu, Hongwei Meng, Yihui Xie, Qian Huang, Xiaowei Ma, Hua Wang, Juanxiu Qin, Qiong Li, Tianming Li, Qiang Xia & Min Li

80 Three Hcp homologs with divergent extended loop regions exhibit different functions in avian pathogenic Escherichia coli - Jiale Ma, Min Sun, Zihao Pan, Wenchao Song, Chengping Lu & Huochun Yao

81 Microencephaly in fetal piglets following in utero inoculation of Zika virus - P. J. Wichgers Schreur, L. van Keulen, D. Anjema, J. Kant & J. Kortekaas

82 Molecular determinants of Yellow Fever Virus pathogenicity in Syrian Golden Hamsters: one mutation away from virulence - Raphaëlle Klitting, Laura Roth, Félix A. Rey & Xavier de Lamballerie

83 Emerging recombinant noroviruses identified by clinical and waste water screening - Jennifer H. Lun, Joanne Hewitt, Alefiya Sitabkhan, John-Sebastian Eden, Daniel Enosi Tuipulotu, Natalie E. Netzler, Leigh Morrell, Juan Merif, Richard Jones, Bixing Huang, David Warrilow, Kelly-Anne Ressler, Mark J. Ferson, Dominic E. Dwyer, Jen Kok, William D. Rawlinson, Daniel Deere, Nicholas D. Crosbie & Peter A. White

84 Biogeography of Leptospira in wild animal communities inhabiting the insular ecosystem of the western Indian Ocean islands and neighboring Africa - Muriel Dietrich, Yann Gomard, Erwan Lagadec, Beza Ramasindrazana, Gildas Le Minter, Vanina Guernier, Aude Benlali, Gerard Rocamora, Wanda Markotter, Steven M. Goodman, Koussay Dellagi & Pablo Tortosa

85 Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus - Yao Deng, Jiaming Lan, Linlin Bao, Baoying Huang, Fei Ye, Yingzhu Chen, Yanfeng Yao, Wenling Wang, Chuan Qin & Wenjie Tan

86 Ranavirus genotypes in the Netherlands and their potential association with virulence in water frogs (Pelophylax spp.) - Bernardo Saucedo, Joseph Hughes, Annemarieke Spitzen-van der Sluijs, Natasja Kruithof, Marc Schills, Jolianne M. Rijks, Mónica Jacinto-Maldonado, Nicolás Suarez, Olga L. M. Haenen, Michal Voorbergen-Laarman, Jan van den Broek, Maarten Gilbert, Andrea Gröne, Steven J. van Beurden & M. Hélène Verheije

87 Whole-genome sequencing of a large collection of Myroides odoratimimus and Myroides odoratus isolates and antimicrobial susceptibility studies - Florian Gunzer, Wolfram W. Rudolph, Boyke Bunk, Isabel Schober, Sonja Peters, Theres Müller, Boris Oberheitmann & Percy Schröttner

88 SIVcpz closely related to the ancestral HIV-1 is less or non-pathogenic to humans in a hu-BLT mouse model - Zhe Yuan, Guobin Kang, Lance Daharsh, Wenjin Fan & Qingsheng Li

89 Enzootic situation and molecular epidemiology of Brucella in livestock from 2011 to 2015 in Qingyang, China - Zhensheng Wang, Juemin Xi, Xiao Hao, Weiwei Deng, Juan Liu, Chunyan Wei, Yuhui Gao, Lianhui Zhang & Heng Wang

90 Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection - Xinyu Zhu, Shudan Liu, Xunlei Wang, Zhaochen Luo, Yuejun Shi, Dang Wang, Guiqing Peng, Huanchun Chen, Liurong Fang & Shaobo Xiao

91 Genomic analysis of oral Campylobacter concisus strains identified a potential bacterial molecular marker associated with active Crohn’s disease - Fang Liu, Rena Ma, Chin Yen Alfred Tay, Sophie Octavia, Ruiting Lan, Heung Kit Leslie Chung, Stephen M. Riordan, Michael C. Grimm, Rupert W. Leong, Mark M. Tanaka, Susan Connor & Li Zhang

92 Two genetically diverse H7N7 avian influenza viruses isolated from migratory birds in central China - Haizhou Liu, Chaochao Xiong, Jing Chen, Guang Chen, Jun Zhang, Yong Li, Yanping Xiong, Runkun Wang, Ying Cao, Quanjiao Chen, Di Liu, Hanzhong Wang & Jianjun Chen

93 Identification of potential urine proteins and microRNA biomarkers for the diagnosis of pulmonary tuberculosis patients - Jieru Wang, Xiaojie Zhu, Xuekai Xiong, Pan Ge, Han Liu, Ningning Ren, Farhan Anwar Khan, Xia Zhou, Li Zhang, Xu Yuan, Xi Chen, Yingyu Chen, Changmin Hu, Ian D. Robertson, Huanchun Chen & Aizhen Guo

94 Wild ducks excrete highly pathogenic avian influenza virus H5N8 (2014–2015) without clinical or pathological evidence of disease - Judith M. A. van den Brand, Josanne H. Verhagen, Edwin J. B. Veldhuis Kroeze, Marco W. G. van de Bildt, Rogier Bodewes, Sander Herfst, Mathilde Richard, Pascal Lexmond, Theo M. Bestebroer, Ron A. M. Fouchier & Thijs Kuiken

95 Isolation and characterization of an astrovirus causing fatal visceral gout in domestic goslings - Qingshui Zhang, Yanxin Cao, Jun Wang, Guanghua Fu, Mengxu Sun, Lijiao Zhang, Li Meng, Guolin Cui, Yu Huang, Xueying Hu & Jingliang Su

96 Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV - Yuting Jiang, Guangyu Zhao, Nianping Song, Pei Li, Yuehong Chen, Yan Guo, Junfeng Li, Lanying Du, Shibo Jiang, Renfeng Guo, Shihui Sun & Yusen Zhou

97 Detection of circulating Mycobacterium tuberculosis-specific DNA by droplet digital PCR for vaccine evaluation in challenged monkeys and TB diagnosis - Neng Song, Yang Tan, Lingyun Zhang, Wei Luo, Qing Guan, Ming-zhe Yan, Ruiqi Zuo, Weixiang Liu, Feng-ling Luo & Xiao-Lian Zhang

98 A novel SigB(Q225P) mutation in Staphylococcus aureus retains virulence but promotes biofilm formation - Hui Liu, Weilong Shang, Zhen Hu, Ying Zheng, Jizhen Yuan, Qiwen Hu, Huagang Peng, Xinyu Cai, Li Tan, Shu Li, Junmin Zhu, Ming Li, Xiaomei Hu, Renjie Zhou, Xiancai Rao & Yi Yang

99 Replication and pathogenic potential of influenza A virus subtypes H3, H7, and H15 from free-range ducks in Bangladesh in mammals - Rabeh El-Shesheny, Mohammed M. Feeroz, Scott Krauss, Peter Vogel, Pamela McKenzie, Richard J. Webby & Robert G. Webster

100 A new subtype of eastern tick-borne encephalitis virus discovered in Qinghai-Tibet Plateau, China - Xiaoyi Dai, Guobao Shang, Shan Lu, Jing Yang & Jianguo Xu

101 Genetic and evolutionary analysis of emerging H3N2 canine influenza virus - Gairu Li, Ruyi Wang, Cheng Zhang, Shilei Wang, Wanting He, Junyan Zhang, Jie Liu, Yuchen Cai, Jiyong Zhou & Shuo Su

102 A novel sheet-like virus particle array is a hallmark of Zika virus infection - Jun Liu, Brandon A. Kline, Tara A. Kenny, Darci R. Smith, Veronica Soloveva, Brett Beitzel, Song Pang, Stephen Lockett, Harald F. Hess, Gustavo Palacios, Jens H. Kuhn, Mei G. Sun & Xiankun Zeng

103 Neurotropism and behavioral changes associated with Zika infection in the vector Aedes aegypti - Julie Gaburro, Asim Bhatti, Jenni Harper, Isabelle Jeanne, Megan Dearnley, Diane Green, Saeid Nahavandi, Prasad N. Paradkar & Jean-Bernard Duchemin

104 Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses - Suli Liu, Wenfei Zhu, Zhaomin Feng, Rongbao Gao, Junfeng Guo, Xiyan Li, Jia Liu, Dayan Wang & Yuelong Shu

105 Re-visiting the evolution, dispersal and epidemiology of Zika virus in Asia - John H.-O. Pettersson, Jon Bohlin, Myrielle Dupont-Rouzeyrol, Ola B. Brynildsrud, Kristian Alfsnes, Van-Mai Cao-Lormeau, Michael W. Gaunt, Andrew K. Falconar, Xavier de Lamballerie, Vegard Eldholm, Didier Musso & Ernest A. Gould

106 Bordetella pertussis isolates vary in their interactions with human complement components - Charlotte Brookes, Irene Freire-Martin, Breeze Cavell, Frances Alexander, Stephen Taylor, Ruby Persaud, Norman Fry, Andrew Preston, Dimitri Diavatopoulos & Andrew Gorringe

107 Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant - Sabine M. G. van der Sanden, Norman Sachs, Sylvie M. Koekkoek, Gerrit Koen, Dasja Pajkrt, Hans Clevers & Katja C. Wolthers

108 MALDI-TOF MS for identification of Tsukamurella species: Tsukamurella tyrosinosolvens as the predominant species associated with ocular infections - Jade L. L. Teng, Ying Tang, Samson S. Y. Wong, Jordan Y. H. Fong, Zhe Zhao, Chun-Pong Wong, Jonathan H. K. Chen, Antonio H. Y. Ngan, Alan K. L. Wu, Kitty S. C. Fung, Tak-Lun Que, Susanna K. P. Lau & Patrick C. Y. Woo

109 Sensitive detection of Treponema pallidum DNA from the whole blood of patients with syphilis by the nested PCR assay - Cuini Wang, Yuanyuan Cheng, Biao Liu, Yuanyuan Wang, Weiming Gong, Yihong Qian, Zhifang Guan, Haikong Lu, Xin Gu, Mei Shi & Pingyu Zhou

110 RBM24 stabilizes hepatitis B virus pregenomic RNA but inhibits core protein translation by targeting the terminal redundancy sequence - Yongxuan Yao, Bo Yang, Huang Cao, Kaitao Zhao, Yifei Yuan, Yingshan Chen, Zhenhua Zhang, Yun Wang, Rongjuan Pei, Jizheng Chen, Xue Hu, Yuan Zhou, Mengji Lu, Chunchen Wu & Xinwen Chen

111 Comparison of the genotypic and phenotypic properties of HIV-1 standard subtype B and subtype B/B′ env molecular clones derived from infections in China - Hui Xie, Jianhui Nie, Qingqing Chen, Weijin Huang & Youchun Wang

112 An epizootic of Chlamydia psittaci equine reproductive loss associated with suspected spillover from native Australian parrots - Cheryl Jenkins, Martina Jelocnik, Melinda L. Micallef, Francesca Galea, Alyce Taylor–Brown, Daniel R. Bogema, Michael Liu, Brendon O’Rourke, Catherine Chicken, Joan Carrick & Adam Polkinghorne

113 Prospective surveillance for influenza A virus in Chinese swine farms - Benjamin D. Anderson, Mai-Juan Ma, Guo-Lin Wang, Zhen-Qiang Bi, Bing Lu, Xian-Jun Wang, Chuang-Xin Wang, Shan-Hui Chen, Yan-Hua Qian, Shao-Xia Song, Min Li, Teng Zhao, Meng-Na Wu, Laura K. Borkenhagen, Wu-Chun Cao & Gregory C. Gray

114 Relationship between circulating vascular endothelial growth factor and its soluble receptor in patients with hemorrhagic fever with renal syndrome - Emil Pal, Misa Korva, Katarina Resman Rus, Nataša Kejžar, Petra Bogovič, Franc Strle & Tatjana Avšič-Županc

115 Novel triple-reassortant influenza viruses in pigs, Guangxi, China - Ping He, Guojun Wang, Yanning Mo, Qingxiong Yu, Xiong Xiao, Wenjuan Yang, Weifeng Zhao, Xuan Guo, Qiong Chen, Jianqiao He, Mingli Liang, Jian Zhu, Yangbao Ding, Zuzhang Wei, Kang Ouyang, Fang Liu, Hui Jian, Weijian Huang, Adolfo García-Sastre & Ying Chen

116 A virus-like particle-based tetravalent vaccine for hand, foot, and mouth disease elicits broad and balanced protective immunity - Wei Zhang, Wenlong Dai, Chao Zhang, Yu Zhou, Pei Xiong, Shuxia Wang, Xiaohua Ye, Qingwei Liu, Dongming Zhou & Zhong Huang

117 The first isolate of Candida auris in China: clinical and biological aspects - Xiaojuan Wang, Jian Bing, Qiushi Zheng, Feifei Zhang, Jingbo Liu, Huizhen Yue, Li Tao, Han Du, Yina Wang, Hui Wang & Guanghua Huang

118 The concordance between upper and lower respiratory microbiota in children with Mycoplasma pneumoniae pneumonia - Wenkui Dai, Heping Wang, Qian Zhou, Xin Feng, Zhiwei Lu, Dongfang Li, Zhenyu Yang, Yanhong Liu, Yinhu Li, Gan Xie, Kunling Shen, Yonghong Yang, Yuejie Zheng & Shuaicheng Li

119 ZIKA virus infection causes persistent chorioretinal lesions - Mohanraj Manangeeswaran, Jennifer L. Kielczewski, H. Nida Sen, Biying C. Xu, Derek. D.C. Ireland, Ian L. McWilliams, Chi-Chao Chan, Rachel R. Caspi & Daniela Verthelyi

120 A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen - Mohanraj Manangeeswaran, Jennifer L. Kielczewski, H. Nida Sen, Biying C. Xu, Derek. D.C. Ireland, Ian L. McWilliams, Chi-Chao Chan, Rachel R. Caspi & Daniela Verthelyi

121 Antigenic characterization of highly pathogenic avian influenza A(H5N1) viruses with chicken and ferret antisera reveals clade-dependent variation in hemagglutination inhibition profiles - Diep Thi Nguyen, Samuel S. Shepard, David Francis Burke, Joyce Jones, Sharmi Thor, Long Van Nguyen, Tho Dang Nguyen, Amanda Balish, Dang Nguyen Hoang, Thanh Long To, Munir Iqbal, David E. Wentworth, Erica Spackman, H Rogier van Doorn, C. Todd Davis & Juliet E. Bryant

122 An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques - Yupeng Feng, Chufang Li, Peiyu Hu, Qian Wang, Xuehua Zheng, Yongkun Zhao, Yi Shi, Songtao Yang, Changhua Yi, Ying Feng, Chunxiu Wu, Linbing Qu, Wei Xu, Yao Li, Caijun Sun, Fu Geroge Gao, Xianzhu Xia, Liqiang Feng & Ling Chen

123 Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis? - Qingyun Liu, Tianyu Zuo, Peng Xu, Qi Jiang, Jie Wu, Mingyu Gan, Chongguang Yang, Ravi Prakash, Guofeng Zhu, Howard E. Takiff & Qian Gao

124 Intestinal microsporidiosis in Strasbourg from 2014 to 2016: emergence of an Enterocytozoon bieneusi genotype of Asian origin - Valentin Greigert, Alexander W. Pfaff, Ahmed Abou-Bacar, Ermanno Candolfi & Julie Brunet

125 Risk factors for extrapulmonary dissemination of tuberculosis and associated mortality during treatment for extrapulmonary tuberculosis - Xu Qian, Duc T. Nguyen, Jianxin Lyu, Andreas E. Albers, Xiaohong Bi & Edward A. Graviss

126 A cross-sectional seroepidemiology study of EV-D68 in China - Shiyang Sun, Fan Gao, Yalin Hu, Lianlian Bian, Xing Wu, Yao Su, Ruixiao Du, Ying Fu, Fengcai Zhu, Qunying Mao & Zhenglun Liang

127 Intravascular haemolysis in severe Plasmodium knowlesi malaria: association with endothelial activation, microvascular dysfunction, and acute kidney injury - Bridget E. Barber, Matthew J. Grigg, Kim A. Piera, Timothy William, Daniel J. Cooper, Katherine Plewes, Arjen M. Dondorp, Tsin W. Yeo & Nicholas M. Anstey

128 Patient-derived avian influenza A (H5N6) virus is highly pathogenic in mice but can be effectively treated by anti-influenza polyclonal antibodies - Weiqi Pan, Haojun Xie, Xiaobo Li, Wenda Guan, Peihai Chen, Beiwu Zhang, Mincong Zhang, Ji Dong, Qian Wang, Zhixia Li, Shufen Li, Zifeng Yang, Chufang Li, Nanshan Zhong, Jicheng Huang & Ling Chen

129 Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia - Jing Bi, Zongchao Gou, Fengzhu Zhou, Yiqing Chen, Jianhua Gan, Jun Liu, Honghai Wang & Xuelian Zhang

130 Diagnostic accuracy evaluation of the conventional and molecular tests for Spinal Tuberculosis in a cohort, head-to-head study - Guirong Wang, Weijie Dong, Tinglong Lan, Jun Fan, Kai Tang, Yuan Li, Guangxuan Yan, Guanglu Jiang, Yifeng Ma, Yuanyuan Shang, Shibing Qin & Hairong Huang

131 Cross-reactive mouse monoclonal antibodies raised against the hemagglutinin of A/Shanghai/1/2013 (H7N9) protect against novel H7 virus isolates in the mouse model - Daniel Stadlbauer, Fatima Amanat, Shirin Strohmeier, Raffael Nachbagauer & Florian Krammer

132 Discovery of Enterovirus A71-like nonstructural genomes in recent circulating viruses of the Enterovirus A species - Kuo-Ming Lee, Yu-Nong Gong, Tzu-Hsuan Hsieh, Andrew Woodman, Nynke H. Dekker, Craig E. Cameron & Shin-Ru Shih

133 Landscape of the genome and host cell response of Mycobacterium shigaense reveals pathogenic features - Haiqin Jiang, Jiya Sun, Yanqing Chen, Zhiming Chen, Le Wang, Wei Gao, Ying Shi, Wenyue Zhang, Youming Mei, Santosh Chokkakula, Varalakshmi Vissa, Taijiao Jiang, Aiping Wu & Hongsheng Wang

134 Changes in intestinal microbiota in HIV-1-infected subjects following cART initiation: influence of CD4+ T cell count - Yongjia Ji, Fengdi Zhang, Renfang Zhang, Yinzhong Shen, Li Liu, Jiangrong Wang, Junyang Yang, Qi Tang, Jingna Xun, Tangkai Qi, Zhenyan Wang, Wei Song, Yang Tang, Jun Chen & Hongzhou Lu

135 Seroprevalence and risk factors for infection with Bartonella bacilliformis in Loja province, Ecuador - Shari L. Lydy, Mauricio S. Lascano, Josselyn E. Garcia-Perez, Amanda J. Williams-Newkirk & Mario J. Grijalva

136 The emerging novel avian leukosis virus with mutations in the pol gene shows competitive replication advantages both in vivo and in vitro - Qi Su, Yang Li, Zhizhong Cui, Shuang Chang & Peng Zhao

137 Comparative genomics of Campylobacter concisus: Analysis of clinical strains reveals genome diversity and pathogenic potential - Matthew R. Gemmell, Susan Berry, Indrani Mukhopadhya, Richard Hansen, Hans L. Nielsen, Mona Bajaj-Elliott, Henrik Nielsen & Georgina L. Hold

138 Xapuri virus, a novel mammarenavirus: natural reassortment and increased diversity between New World viruses - Jorlan Fernandes, Alexandro Guterres, Renata Carvalho de Oliveira, John Chamberlain, Kuiama Lewandowski, Bernardo Rodrigues Teixeira, Thayssa Alves Coelho, Charle Ferreira Crisóstomo, Cibele Rodrigues Bonvicino, Paulo Sérgio D’Andrea, Roger Hewson & Elba Regina Sampaio de Lemos

139 Swine influenza viruses in Northern Vietnam in 2013–2014 - Eugénie Baudon, Daniel K. W. Chu, Dao Duy Tung, Pham Thi Nga, Hoang Vu Mai Phuong, Nguyen Le Khanh Hang, Le Thi Thanh, Nguyen Thanh Thuy, Nguyen Cong Khanh, Lê Quynh Mai, Nguyen Viet Khong, Benjamin J. Cowling, Marisa Peyre & Malik Peiris

140 Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clones II and III in Lima, Peru - Saúl Levy-Blitchtein, Ignasi Roca, Stefany Plasencia-Rebata, William Vicente-Taboada, Jorge Velásquez-Pomar, Laura Muñoz, Javier Moreno-Morales, Maria J. Pons, Juana del Valle-Mendoza & Jordi Vila

141 Evaluation of the VITEK MS knowledge base version 3.0 for the identification of clinically relevant Mycobacterium species - LiuLin Luo, Wen Cao, WeiWei Chen, RanRan Zhang, LinJie Jing, HuiPing Chen, FangYou Yu & Jun Yue

142 Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae - Xiaoming Wang, Yao Wang, Ying Zhou, Jiyun Li, Wenjuan Yin, Shaolin Wang, Suxia Zhang, Jianzhong Shen, Zhangqi Shen & Yang Wang

143 Capsular serovars of virulent Capnocytophaga canimorsus are shared by the closely related species C. canis and C. cynodegmi - Francesco Renzi, Estelle Hess, Melanie Dol, Dunia Koudad, Elodie Carlier, Maria Ohlén, Edward Moore & Guy Richard Cornelis

144 Long-term HEV carriers without antibody seroconversion among eligible immunocompetent blood donors - Gui-Ping Wen, Chang-Rong Chen, Xiu-Yu Song, Zi-Min Tang, Wen-Fang Ji, Si-Ling Wang, Ke Zhang, Jun Zhang, Shan-Hai Ou, Zi-Zheng Zheng & Ning-Shao Xia

145 Evolution of tigecycline- and colistin-resistant CRKP (carbapenem-resistant Klebsiella pneumoniae) in vivo and its persistence in the GI tract - Rong Zhang, Ning Dong, Yonglu Huang, Hongwei Zhou, Miaomiao Xie, Edward Wai-Chi Chan, Yanyan Hu, Jiachang Cai & Sheng Chen

146 LtpA, a CdnL-type CarD regulator, is important for the enzootic cycle of the Lyme disease pathogen - Tong Chen, Xuwu Xiang, Haijun Xu, Xuechao Zhang, Bibi Zhou, Youyun Yang, Yongliang Lou & X. Frank Yang

147 First cases and risk factors of super yeast Candida auris infection or colonization from Shenyang, China - Sufei Tian, Chen Rong, Hua Nian, Fushun Li, Yunzhuo Chu, Shitong Cheng & Hong Shang

148 Zika convalescent macaques display delayed induction of anamnestic cross-neutralizing antibody responses after dengue infection - William G. Valiant, Yan-Jang S. Huang, Dana L. Vanlandingham, Stephen Higgs, Mark G. Lewis & Joseph J. Mattapallil

149 A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential - Christian Grund, Donata Hoffmann, Reiner Ulrich, Mahmoud Naguib, Jan Schinköthe, Bernd Hoffmann, Timm Harder, Sandra Saenger, Katja Zscheppang, Mario Tönnies, Stefan Hippenstiel, Andreas Hocke, Thorsten Wolff & Martin Beer

150 Continuous decline of hepatitis E virus seroprevalence in southern Germany despite increasing notifications, 2003–2015 - Hannah Mahrt, Mathias Schemmerer, Gundula Behrens, Michael Leitzmann, Wolfgang Jilg & Jürgen J. Wenzel

151 Subinhibitory concentrations of resveratrol reduce alpha-hemolysin production in Staphylococcus aureus isolates by downregulating saeRS - Jingjing Duan, Meilan Li, Zhihao Hao, Xiaofei Shen, Li Liu, Ye Jin, Shanshan Wang, Yinjuan Guo, Lehe Yang, Liangxing Wang & Fangyou Yu

152 A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway - Peng Du, Shi-Jun Li, David M. Ojcius, Kai-Xuan Li, Wei-Lin Hu, Xu’ai Lin, Ai-Hua Sun & Jie Yan

153 Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae - Jin-xin Zheng, Zhi-wei Lin, Xiang Sun, Wei-hong Lin, Zhong Chen, Yang Wu, Guo-bin Qi, Qi-wen Deng, Di Qu & Zhi-jian Yu

154 Systemic and mucosal humoral immune responses induced by the JY-adjuvanted nasal spray H7N9 vaccine in mice - Jing Xu, Shuxiang Li, Xinyi Wang, Jing Liu, Pu Shan, Ya Zhou, Jing Zhao, Zhibiao Wang, Cui Xu, Meili Chen, Ze Chen, Kai Zhao & Di Qu

155 TSC1 and DEPDC5 regulate HIV-1 latency through the mTOR signaling pathway - Shan Jin, Qibin Liao, Jian Chen, Linxia Zhang, Qian He, Huanzhang Zhu, Xiaoyan Zhang & Jianqing Xu

156 Sequence analysis of integrated hepatitis B virus DNA during HBeAg-seroconversion - Magdalena Agnieszka Budzinska, Nicholas Adam Shackel, Stephan Urban & Thomas Tu

157 Phenotypic and molecular analysis of nontypeable Group B streptococci: identification of cps2a and hybrid cps2a/cps5 Group B streptococcal capsule gene clusters - Areej Alhhazmi & Gregory J. Tyrrell

158 Adaptive mutation F772S-enhanced p7-NS4A cooperation facilitates the assembly and release of hepatitis C virus and is associated with lipid droplet enlargement - Xiaobing Duan, Muhammad Ikram Anwar, Zhanxue Xu, Ling Ma, Guosheng Yuan, Yiyi Chen, Xi Liu, Jinyu Xia, Yuanping Zhou & Yi-Ping Li

159 Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection - Lunzhi Yuan, Xuan Liu, Liang Zhang, Yali Zhang, Yao Chen, Xiaoling Li, Kun Wu, Jiali Cao, Wangheng Hou, Yuqiong Que, Jun Zhang, Hua Zhu, Quan Yuan, Qiyi Tang, Tong Cheng & Ningshao Xia

160 Tracking microevolution events among ST11 carbapenemase-producing hypervirulent Klebsiella pneumoniae outbreak strains - Ning Dong, Xuemei Yang, Rong Zhang, Edward Wai-Chi Chan & Sheng Chen

161 Seroprevalence of TBEV in bank voles from Poland—a long-term approach - Maciej Grzybek, Mohammed Alsarraf, Katarzyna Tołkacz, Jolanta Behnke-Borowczyk, Beata Biernat, Joanna Stańczak, Aneta Strachecka, Leszek Guz, Klaudiusz Szczepaniak, Jerzy Paleolog, Jerzy M. Behnke & Anna Bajer

162 Multiple domains of bacterial and human Lon proteases define substrate selectivity - Lihong He, Dongyang Luo, Fan Yang, Chunhao Li, Xuegong Zhang, Haiteng Deng & Jing-Ren Zhang

163 Attenuation of highly pathogenic avian influenza A(H5N1) viruses in Indonesia following the reassortment and acquisition of genes from low pathogenicity avian influenza A virus progenitors - Ni Luh Putu Indi Dharmayanti, Sharmi W. Thor, Natosha Zanders, Risza Hartawan, Atik Ratnawati, Yunho Jang, Marisela Rodriguez, David L. Suarez, Gina Samaan, Pudjiatmoko & C. Todd Davis

164 An emerging novel goose astrovirus associated with gosling gout disease, China - Xinyu Zhang, Dan Ren, Tuofan Li, Huayan Zhou, Xiaoyu Liu, Xiaobo Wang, Hao Lu, Wei Gao, Yajuan Wang, Xiaoyan Zou, Huaichang Sun & Jianqiang Ye

165 Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats - Dan Hu, Changqiang Zhu, Lele Ai, Ting He, Yi Wang, Fuqiang Ye, Lu Yang, Chenxi Ding, Xuhui Zhu, Ruicheng Lv, Jin Zhu, Bachar Hassan, Youjun Feng, Weilong Tan & Changjun Wang

166 A live attenuated vaccine prevents replication and transmission of H7N9 highly pathogenic influenza viruses in mammals - Wenyu Yang, Xin Yin, Lizheng Guan, Mei Li, Shujie Ma, Jianzhong Shi, Guohua Deng, Yasuo Suzuki & Hualan Chen

167 Rv2346c enhances mycobacterial survival within macrophages by inhibiting TNF-α and IL-6 production via the p38/miRNA/NF-κB pathway - Jing Yao, Xingran Du, Sixia Chen, Yan Shao, Kaili Deng, Mingzi Jiang, Jingning Liu, Ziyan Shen, Xiaolin Chen & Ganzhu Feng

168 miR-1303 regulates BBB permeability and promotes CNS lesions following CA16 infections by directly targeting MMP9 - Jie Song, Yajie Hu, Hongzhe Li, Xing Huang, Huiwen Zheng, Yunguang Hu, Jingjing Wang, Xi Jiang, Jiaqi Li, Zening Yang, Haitao Fan, Lei Guo, Haijing Shi, Zhanlong He, Fengmei Yang, Xi Wang, Shaozhong Dong, Qihan Li & Longding Liu

169 Saliva as a source of reagent to study human susceptibility to avian influenza H7N9 virus infection - Ming Tan, Lunbiao Cui, Xiang Huo, Ming Xia, Fengjuan Shi, Xiaoyan Zeng, Pengwei Huang, Weiming Zhong, Weiwei Li, Ke Xu, Liling Chen, Minghao Zhou & Xi Jiang

170 N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro - Minxi Wei, Daning Wang, Zhihai Li, Shuo Song, Xianglin Kong, Xiaobing Mo, Yurou Yang, Maozhou He, Zhongyi Li, Bo Huang, Zhijie Lin, Huirong Pan, Qingbing Zheng, Hai Yu, Ying Gu, Jun Zhang, Shaowei Li & Ningshao Xia

171 Live Zika virus chimeric vaccine candidate based on a yellow fever 17-D attenuated backbone - Franck Touret, Magali Gilles, Raphaelle Klitting, Fabien Aubry, Xavier de Lamballerie & Antoine Nougairède

172 Differential transmission of Asian and African Zika virus lineages by Aedes aegypti from New Caledonia - Elodie Calvez, Olivia O’Connor, Morgane Pol, Dominique Rousset, Oumar Faye, Vincent Richard, Arnaud Tarantola & Myrielle Dupont-Rouzeyrol

173 Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding - Chien-Ju Lin, Ching-Hsuan Liu, Jonathan Y. Wang, Chun-Ching Lin, Yi-Fang Li, Christopher D. Richardson & Liang-Tzung Lin

174 Tree shrew as a new animal model to study the pathogenesis of avian influenza (H9N2) virus infection - Runfeng Li, Bing Yuan, Xueshan Xia, Sheng Zhang, Qiuling Du, Chunguang Yang, Na Li, Jin Zhao, Yunhui Zhang, Rongping Zhang, Yue Feng, Jianlin Jiao, Malik Peiris, Nanshan Zhong, Chris Ka Pun Mok & Zifeng Yang

175 Zika virus shedding in the stool and infection through the anorectal mucosa in mice - Chunfeng Li, Yong-Qiang Deng, Shulong Zu, Natalie Quanquin, Jingzhe Shang, Min Tian, Xue Ji, Na-Na Zhang, Hao-Long Dong, Yan-Peng Xu, Ling-Zhai Zhao, Fu-Chun Zhang, Xiao-Feng Li, Aiping Wu, Genhong Cheng & Cheng-Feng Qin

176 Identification and genetic characterization of a novel parvovirus associated with serum hepatitis in horses in China - Gang Lu, Lingshuang Sun, Jiajun Ou, Haibin Xu, Liyan Wu & Shoujun Li

177 Genome-wide characterization of the seasonal H3N2 virus in Shanghai reveals natural temperature-sensitive strains conferred by the I668V mutation in the PA subunit - Dong Wei, De-Ming Yu, Ming-jie Wang, Dong-hua Zhang, Qi-jian Cheng, Jie-Ming Qu & Xin-xin Zhang

178 Identification of a novel broadly HIV-1-neutralizing antibody from a CRF01_AE-infected Chinese donor - Bin Ju, Dan Li, Li Ren, Jiali Hou, Yanling Hao, Hua Liang, Shuo Wang, Jiang Zhu, Min Wei & Yiming Shao

179 Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding - Adriana Osickova, Nataliya Balashova, Jiri Masin, Miroslav Sulc, Jana Roderova, Tomas Wald, Angela C. Brown, Evan Koufos, En Hyung Chang, Alexander Giannakakis, Edward T. Lally & Radim Osicka

180 Immunogenicity and protective efficacy against Treponema pallidum in New Zealand rabbits immunized with plasmid DNA encoding flagellin - Kang Zheng, Man Xu, Yongjian Xiao, Haodang Luo, Yafeng Xie, Jian Yu, Manyi Tan, Yumeng Li, Feijun Zhao, Tiebing Zeng & Yimou Wu

181 The molecular basis of antigenic variation among A(H9N2) avian influenza viruses - Thomas P. Peacock, William T. Harvey, Jean-Remy Sadeyen, Richard Reeve & Munir Iqbal

182 Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells - Jana Sirmarova, Jiri Salat, Martin Palus, Vaclav Hönig, Helena Langhansova, Michael R. Holbrook & Daniel Ruzek

183 Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017 - Cong Chen, Zuliang Liu, Liguo Liu, Yan Xiao, Jianmin Wang & Qi Jin

184 Pathogenesis and genetic characteristics of novel reassortant low-pathogenic avian influenza H7 viruses isolated from migratory birds in the Republic of Korea in the winter of 2016–2017 - Yu-Na Lee, Sun-Ha Cheon, Eun-Kyoung Lee, Gyeong-Beom Heo, You-Chan Bae, Seong-Joon Joh, Myoung-Heon Lee & Youn-Jeong Lee

185 Restriction of Zika virus infection and transmission in Aedes aegypti mediated by an insect-specific flavivirus - Hannah Romo, Joan L. Kenney, Bradley J. Blitvich & Aaron C. Brault

186 The impact of combined gene mutations in inhA and ahpC genes on high levels of isoniazid resistance amongst katG non-315 in multidrug-resistant tuberculosis isolates from China - Liguo Liu, Fengting Jiang, Lihong Chen, Bing Zhao, Jie Dong, Lilian Sun, Yafang Zhu, Bo Liu, Yang Zhou, Jian Yang, Yanlin Zhao, Qi Jin & Xiaobing Zhang

187 A neonatal mouse model of central nervous system infections caused by Coxsackievirus B5 - Qunying Mao, Xiaotian Hao, Yalin Hu, Ruixiao Du, Shuhui Lang, Lianlian Bian, Fan Gao, Ce Yang, Bopei Cui, Fengcai Zhu, Lianzhong Shen & Zhenglun Liang

188 Upregulation of HBV transcription by sodium taurocholate cotransporting polypeptide at the postentry step is inhibited by the entry inhibitor Myrcludex B - Kaitao Zhao, Shuhui Liu, Yingshan Chen, Yongxuan Yao, Ming Zhou, Yifei Yuan, Yun Wang, Rongjuan Pei, Jizheng Chen, Xue Hu, Yuan Zhou, He Zhao, Mengji Lu, Chunchen Wu & Xinwen Chen

189 Characterising routes of H5N1 and H7N9 spread in China using Bayesian phylogeographical analysis - Chau M. Bui, Dillon C. Adam, Edwin Njoto, Matthew Scotch & C. Raina MacIntyre

190 Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis - Chao-Fu Yang, Balraj Gopula, Jian-Jong Liang, Jin-Kun Li, Si-Yu Chen, Yi-Ling Lee, Ching S. Chen & Yi-Ling Lin

191 Experimental transmission of Zika virus by Aedes japonicus japonicus from southwestern Germany - Stephanie Jansen, Anna Heitmann, Renke Lühken, Hanna Jöst, Michelle Helms, Olli Vapalahti, Jonas Schmidt-Chanasit & Egbert Tannich

192 Genetic characterization and molecular epidemiological analysis of novel enterovirus EV-B80 in China - Zhenzhi Han, Yong Zhang, Keqiang Huang, Hui Cui, Mei Hong, Haishu Tang, Yang Song, Qian Yang, Shuangli Zhu, Dongmei Yan & Wenbo Xu

193 Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016) - Agustina Rimondi, Ana S. Gonzalez-Reiche, Valeria S. Olivera, Julieta Decarre, Gabriel J. Castresana, Marcelo Romano, Martha I. Nelson, Harm van Bakel, Ariel J. Pereda, Lucas Ferreri, Ginger Geiger & Daniel R. Perez

194 Potential of Aedes albopictus as a bridge vector for enzootic pathogens at the urban-forest interface in Brazil - Taissa Pereira dos Santos, David Roiz, Filipe Vieira Santos de Abreu, Sergio Luiz Bessa Luz, Marcelo Santalucia, Davy Jiolle, Maycon Sebastiao Alberto Santos Neves, Frédéric Simard, Ricardo Lourenço-de-Oliveira & Christophe Paupy

195 Filamentation in Candida auris, an emerging fungal pathogen of humans: passage through the mammalian body induces a heritable phenotypic switch - Huizhen Yue, Jian Bing, Qiushi Zheng, Yulong Zhang, Tianren Hu, Han Du, Hui Wang & Guanghua Huang

196 The importance of study duration and spatial scale in pathogen detection—evidence from a tick-infested island - Jani Jukka Sormunen, Tero Klemola, Jari Hänninen, Satu Mäkelä, Ilppo Vuorinen, Ritva Penttinen, Ilari Eerikki Sääksjärvi & Eero Juhani Vesterinen

197 Altered gut microbiota after traumatic splenectomy is associated with endotoxemia - Hua Zhu, Yang Liu, Shengda Li, Ye Jin, Lei Zhao, Fuya Zhao, Jing Feng, Wei Yan & Yunwei Wei

198 Zika virus infection in human placental tissue explants is enhanced in the presence of dengue virus antibodies in-vitro - Kyra Hermanns, Claudia Göhner, Anne Kopp, Andre Schmidt, Waltraut M. Merz, Udo R. Markert, Sandra Junglen & Christian Drosten

199 Seroepidemiological investigation of HAdV-4 infection among healthy adults in China and in Sierra Leone, West Africa - Busen Wang, Jianhua Li, Shipo Wu, Yi Chen, Zhe Zhang, Yanfang Zhai, Qiang Guo, Jinlong Zhang, Xiaohong Song, Zhenghao Zhao, Lihua Hou & Wei Chen

200Severity of enterovirus A71 infection in a human SCARB2 knock-in mouse model is dependent on infectious strain and route - Junping Zhu, Ning Chen, Shuya Zhou, Kai Zheng, Lin Sun, Yuxiao Zhang, Lina Cao, Xiaoyan Zhang, Qiaoyan Xiang, Zhiyun Chen, Chenfei Wang, Changfa Fan & Qiushui He

201Novel type of pilus associated with a Shiga-toxigenic E. coli hybrid pathovar conveys aggregative adherence and bacterial virulence - Christina Lang, Angelika Fruth, Gudrun Holland, Michael Laue, Sabrina Mühlen, Petra Dersch & Antje Flieger

202Fiber2 and hexon genes are closely associated with the virulence of the emerging and highly pathogenic fowl adenovirus 4 - Yuhan Zhang, Ruxin Liu, Kaiyue Tian, Zeng Wang, Xia Yang, Dongsheng Gao, Youming Zhang, Jun Fu, Hailong Wang & Jun Zhao

203Emergence of a dalbavancin induced glycopeptide/lipoglycopeptide non-susceptible Staphylococcus aureus during treatment of a cardiac device-related endocarditis - Manuel Kussmann, Matthias Karer, Markus Obermueller, Katy Schmidt, Wolfgang Barousch, Doris Moser, Marion Nehr, Michael Ramharter, Wolfgang Poeppl, Athanasios Makristathis, Stefan Winkler, Florian Thalhammer, Heinz Burgmann & Heimo Lagler

204Evolutionary evidence for multi-host transmission of cetacean morbillivirus - Wendy K. Jo, Jochen Kruppa, Andre Habierski, Marco van de Bildt, Sandro Mazzariol, Giovanni Di Guardo, Ursula Siebert, Thijs Kuiken, Klaus Jung, Albert Osterhaus & Martin Ludlow

205A viral race for primacy: co-infection of a natural pair of low and highly pathogenic H7N7 avian influenza viruses in chickens and embryonated chicken eggs - Annika Graaf, Reiner Ulrich, Pavlo Maksimov, David Scheibner, Susanne Koethe, Elsayed M. Abdelwhab, Thomas C. Mettenleiter, Martin Beer & Timm Harder

206Broadly neutralizing monoclonal antibodies against human adenovirus types 55, 14p, 7, and 11 generated with recombinant type 11 fiber knob - Xingui Tian, Ye Fan, Zhenwei Liu, Ling Zhang, Jiayi Liao, Zhichao Zhou, Xiao Li, Tiantian Liu, Wenkuan Liu, Hongling Qiu & Rong Zhou

207Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins - Susanna K. P. Lau, Rachel Y. Y. Fan, Hayes K. H. Luk, Longchao Zhu, Joshua Fung, Kenneth S. M. Li, Emily Y. M. Wong, Syed Shakeel Ahmed, Jasper F. W. Chan, Raven K. H. Kok, Kwok-Hung Chan, Ulrich Wernery, Kwok-Yung Yuen & Patrick C. Y. Woo

208Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea - Chunhui Li, Céline Harmanus, Duolong Zhu, Xiujuan Meng, Shaohui Wang, Juping Duan, Sidi Liu, Chenchao Fu, Pengcheng Zhou, Ruisi Liu, Anhua Wu, Ed J. Kuijper, Wiep Klaas Smits, Lei Fu & Xingmin Sun

209Multidrug-resistant tuberculosis (MDR-TB) strain infection in macaques results in high bacilli burdens in airways, driving broad innate/adaptive immune responses - Enzhuo Yang, Rui Yang, Ming Guo, Dan Huang, Wandang Wang, Zhuoran Zhang, Crystal Chen, Feifei Wang, Wenzhe Ho, Ling Shen, Heping Xiao, Zheng W. Chen & Hongbo Shen

210Associating H2O2-and NO-related changes in the proteome of Mycobacterium smegmatis with enhanced survival in macrophage - Naadir Ganief, Jessica Sjouerman, Claudia Albeldas, Kehilwe C. Nakedi, Clemens Hermann, Bridget Calder, Jonathan M. Blackburn & Nelson C. Soares

211Complete genome analysis demonstrates multiple introductions of enterovirus 71 and coxsackievirus A16 recombinant strains into Thailand during the past decade - Pirom Noisumdaeng, Kantima Sangsiriwut, Jarunee Prasertsopon, Chompunuch Klinmalai, Sunchai Payungporn, Anek Mungaomklang, Kulkanya Chokephaibulkit, Rome Buathong, Arunee Thitithanyanont & Pilaipan Puthavathana

AUTHOR CORRECTION

212Author Correction: Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris - Johanna Rhodes, Alireza Abdolrasouli, Rhys A. Farrer, Christina A. Cuomo, David M. Aanensen, Darius Armstrong-James, Matthew C. Fisher & Silke Schelenz

213Author Correction: Prevalence and characteristics of hypoxic hepatitis in the largest single-centre cohort of avian influenza A(H7N9) virus-infected patients with severe liver impairment in the intensive care unit - Yi Min Zhang, Ji Min Liu, Liang Yu, Ning Zhou, Wei Ding, Shu Fa Zheng, Ding Shi & Lan Juan Li

214Author Correction: Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens - Ashrafali M. Ismail, Tiange Cui, Kalpana Dommaraju, Gurdeep Singh, Shoaleh Dehghan, Jason Seto, Susmita Shrivastava, Nadia B. Fedorova, Neha Gupta, Timothy B. Stockwell, Rebecca Halpin, Ramana Madupu, Albert Heim, Adriana E. Kajon, Eric G. Romanowski, Regis P. Kowalski, Jambulingam Malathi, Kuzhanthai L. Therese, Hajib Narahari Madhavan, Qiwei Zhang, Leonardo J. Ferreyra, Morris S. Jones, Jaya Rajaiya, David W. Dyer, James Chodosh & Donald Seto