TABLE OF CONTENT 2019

CORRESPONDENCE

1 Housecleaning of pyrimidine nucleotide pool coordinates metabolic adaptation of. nongrowing Mycobacterium tuberculosis - Kun-Xiong Shi, Yong-Kai Wu, Bi-Kui Tang, Guo-Ping ZhaoORCID & Liang-Dong LyuORCID

2 Naturally infected Aedes aegypti collected during a Zika virus outbreak have viral titres consistent with transmission - Sasha R. Azar, Esteban E. Diaz-Gonzalez, Rogelio Danis-Lonzano, Ildefonso Fernandez-Salas & Scott C. Weaver

3 Canine bufavirus in faeces and plasma of dogs with diarrhoea, China - Jingjiao Li, Li Cui, Xutao Deng, Xiangqian Yu, Zhonghai Zhang, Zhibiao Yang, Eric Delwart, Wen Zhang & Xiuguo Hua

4 Genome sequences derived from pig and dried blood pig feed samples provide important insights into the transmission of African swine fever virus in China in 2018 - Xuexia Wen, Xijun He, Xiang Zhang, Xianfeng Zhang, Liling Liu, Yuntao Guan, Ying Zhang & Zhigao Bu show less

5 Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China - Meng Li, Shengyong Feng, Sanfu Lv, Jing Luo, Jianli Guo, Jianhua Sun & Hongxuan He

6 Single-dose replicon particle vaccine provides complete protection against Crimean-Congo hemorrhagic fever virus in mice - Florine E. M. Scholte, Jessica R. Spengler, Stephen R. Welch, Jessica R. Harmon, JoAnn D. Coleman-McCray, Brendan T. Freitas, Markus H. Kainulainen, Scott D. Pegan, Stuart T. Nichol, Éric Bergeron & Christina F. Spiropoulou

7 Rickettsia typhi infection in severe fever with thrombocytopenia patients, China - Shao-Fei Zhang, Juan Du, Xian-Miao Mi, Qing-Bin Lu, Jie-Ying Bai, Ning Cui, Zhen-Dong Yang, Zhi-Bo Wang, Xiao-Ai Zhang, Pan-He Zhang, Hao Li & Wei Liu show less

8 Avian influenza virus detection, temporality and co-infection in poultry in Cambodian border provinces, 2017–2018 - Erik A. Karlsson, Srey Viseth Horm, Songha Tok, Sothyra Tum, Wantanee Kalpravidh, Filip Claes, Kristina Osbjer & Philippe Dussart

9 New evidence for the east–west spread of the highly pathogenic avian influenza H5N1 virus between Central Asian and east Asian-Australasian flyways in China - Weiyue Meng, Qiqi Yang, Bram Vrancken, Zhuo Chen, Dongping Liu, Lixia Chen, Xiang Zhao, Sarah François, Tian Ma, Ruyi Gao, Wendong Ru, Yunfeng Li, Hongxuan He, Guogang Zhang, Huaiyu Tian & Jun Lu

10 Babesia divergens in human in Gansu province, China - Jinming Wang, Shangdi Zhang, Jingqiong Yang, Junlong Liu, Dekui Zhang, Youquan Li, Jianxun Luo, Guiquan Guan & Hong Yin

11 Detection of African swine fever virus in pork products brought to Taiwan by travellers - Wen-Hung Wang, Chih-Yen Lin, Max R. Chang Ishcol, Aspiro Nayim Urbina, Wanchai Assavalapsakul, Arunee Thitithanyanont, Po-Liang Lu, Yen-Hsu Chen & Sheng-Fan Wang

12 First case of laboratory-confirmed severe fever with thrombocytopenia syndrome disease revealed the risk of SFTSV infection in Xinjiang, China - Liying Zhu, Feifei Yin, Abulimiti Moming, Jingyuan Zhang, Bo Wang, Lijuan Gao, Jianwen Ruan, Qiaoli Wu, Na Wu, Hualin Wang, Fei Deng, Gang Lu & Shu Shen

13 Plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from food-producing animals, China, 2008–2018 - Chengtao Sun, Mingquan Cui, Shan Zhang, Hejia Wang, Li Song, Chunping Zhang, Qi Zhao, Dejun Liu, Yang Wang, Jianzhong Shen, Shixin Xu & Congming Wu

14 Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017–2018 - Qianqin Yuan, Yamei Li, Leshan Xiu, Chi Zhang, Yaoyang Fu, Chuanhao Jiang, Lingli Tang & Junping Peng

15 Direct evidence of an extra-intestinal cycle of Toxoplasma gondii in tigers (Panthera tigris) by isolation of viable strains - Yurong Yang, Hui Dong, Ruijing Su, Nan Jiang, Tongyi Li, Chunlei Su, Ziguo Yuan & Longxian Zhang

16 Survival and persistence of Nipah virus in blood and tissue culture media - Sophie J. Smither, Lin S. Eastaugh, James S. Findlay, Lyn M. O’Brien, Ruth Thom & Mark S. Lever

17 Pig as a reservoir of CRISPR type TST4 Salmonella enterica serovar. Typhimurium monophasic variant during 2009–2017 in China - Xiaolei Xie, Zhenyu Wang, Kai Zhang, Yang Li, Yachen Hu, Zhiming Pan, Xiang ChenORCID Icon, Qiuchun Li, Icon & Xinan Jiao

18 Return of the founder Chikungunya virus to its place of introduction into Brazil is revealed by genomic characterization of exanthematic disease cases - Zuinara Pereira Gusmão Maia, Felicidade Mota Pereira, Rodrigo Fabiano do Carmo Said, Vagner. Fonsecan, Tiago Gräf, Fernanda de Bruycker Nogueira, Vanessa Brandão Nardy, Joilson Xavier, Maricelia Lima Maia, André L. Abreu, Carlos F. Campelo de Albuquerque, Wanderson Kleber Oliveira, Julio Croda, Ana Maria Bispo de Filippis, Rivaldo Venancio Cunha, Jose Lourenço, Tulio de Oliveira, Nuno Rodrigues Faria, Luiz Carlos Junior Alcantara & Marta Giovanetti

REVIEW

19 Endogenous non-retroviral elements in genomes of Aedes mosquitoes and vector competence - Vincent Houé, Mariangela Bonizzoni & Anna-Bella Failloux

20 Clostridium difficile ribotype 017 – characterization, evolution and epidemiology of the dominant strain in Asia - Korakrit Imwattana, Daniel R. Knight, Brian Kullin, Deirdre A. Collins, Papanin Putsathit, Pattarachai Kiratisin & Thomas V. Riley

21 Antibodies and vaccines against Middle East respiratory syndrome coronavirus - Jiuyang Xu, Wenxu Jia, Pengfei Wang, Senyan Zhang, Xuanling Shi, Xinquan Wang & Linqi Zhang

22 Klebsiella variicola: an emerging pathogen in humans - Nadia Rodríguez-Medina, Humberto Barrios-Camacho, Josefina Duran-Bedolla & Ulises Garza-Ramos

23 Tularemia as a waterborne disease: a review - Aurélie Hennebique, Sandrine Boisset & Max Maurin

24 Mycobacterial mannose-capped lipoarabinomannan: a modulator bridging innate and adaptive immunity - Kai-Liang Zhou, Xin Li, Xiao-Lian Zhang & Qin Pan

25 Dengue haemorrhagic fever: a job done via exosomes? - Ritu Mishra, Sneh Lata, Amjad Ali & Akhil C. Banerjea

26 Are adenoviruses zoonotic? A systematic review of the evidence - Laura K. Borkenhagen, Jane K. Fieldhouse, Donald Seto & Gregory C. Gray

27 HIV-1 pseudoviruses constructed in China regulatory laboratory - Jianhui Nie, Weijin Huang, Qiang Liu & Youchun Wang

COMMENT

28 Pseudorabies virus: a neglected zoonotic pathogen in humans? - Gary Wong, Jiahai Lu, Wenhong Zhang & George Fu Gao

29 Successful treatment of a Candida auris intra-articular infection - Scott C. Roberts, Teresa R. Zembower, Maureen K. Bolon, Anish R. Kadakia, Jasen H. Gilley, Jason H. Ko, Jessica Clark, Sharon Ward-Fore & Babafemi O. Taiwo

30 The first imported case of melioidosis in a patient in central China - Youhua Yuan, Zonghui Yao, Erhui Xiao, Jiangfeng Zhang, Baoya Wang, Bing Ma, Yi Li, Wenjuan Yan, Shanmei Wang, Qiong Ma, Junhong Xu, Yuming Wang & Enguo Fan

31 Myths in the laboratory diagnosis of HIV infection - Hongzhou Lu & Yi-Wei Tang

ARTICLE

32 Isolation of group B Streptococcus with reduced β-lactam susceptibility from pregnant women - Hiroaki Moroi, Kouji Kimura, Tomomi Kotani, Hiroyuki Tsuda, Hirotsugu Banno, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Takashi Mitsui, Mamoru Yamashita, Fumitaka Kikkawa & Yoshichika Arakawa

33 Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells - Sujit Pujhari, Marco Brustolin, Vanessa M. MaciasO, Ruth H. Nissly, Masashi Nomura, Suresh V. Kuchipudi & Jason L. Rasgon

34 A Listeria monocytogenes ST2 clone lacking chitinase ChiB from an outbreak of non-invasive gastroenteritis - Sven Halbedel, Rita Prager, Sangeeta Banerji, Sylvia Kleta, Eva Trost, Gopala Nishanth, Georg Alles, Christina Hölzel, Friederike Schlesiger, Ariane Pietzka, Dirk Schlüter & Antje Flieger

35 Characterization of the emerging multidrug-resistant Salmonella enterica serovar Indiana strains in China - Jiansen Gong , Ximin Zeng, Ping Zhang, Di Zhang, Chengming Wang & Jun Lin

36 Protection against homo and hetero-subtypic influenza A virus by optimized M2e DNA vaccine - Yanfeng Yao , Huadong Wang, Jianjun Chen, Zhiyong Shao, Bin He, Jie Chen, Jiaming Lan, Quanjiao Chen & Ze Chen

37 Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation - Jie Ren , Yu Sang, Ran Qin, Yang Su, Zhongli Cui, Zhiguo Mang, Hao Li, Shaoyong Lu, Jian Zhang, Sen Cheng, Xiaoyun Liu, Jixi Li, Jie Lu, Wenjuan Wu, Guo-Ping Zhao, Feng Shao & Yu-Feng Yao

38 Chikungunya virus in Asia – Pacific: a systematic review - B. M. C. Randika Wimalasiri-Yapa, Liesel Stassen, Xiaodong Huang, Louise M. Hafner, Wenbiao Hu, Gregor J. Devine, Laith Yakob, Cassie C. Jansen, Helen M. Faddy, Elvina Viennet & Francesca D. Frentiu

39 The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro. and in vivo - Sebastian Schloer, Jonas Goretzko, Alexander Kühnl, Linda Brunotte, Stephan LudwigO & Ursula Rescher

40 Diverse biological characteristics and varied virulence of H7N9 from Wave 5 - Linlin Bao , Yuhai Bi, Gary Wong, Wenbao Qi, Fengdi Li, Qi Lv, Liang Wang, Fei Liu, Yang Yang, Cheng Zhang, William J. Liu, Chuansong Quan, Weixin Jia, Yingxia Liu, Wenjun Liu, Ming Liao, George F. Gao & Chuan Qin

41 Middle East respiratory syndrome coronavirus infection in non-camelid domestic. Mammals - Ahmed Kandeil, Mokhtar Gomaa, Mahmoud Shehata, Ahmed El-Taweel, Ahmed E. Kayed, Awatef Abiadh, Jamel Jrijer, Yassmin Moatasim, Omnia Kutkat, Ola Bagato, Sara Mahmoud, Ahmed Mostafa, Rabeh El-Shesheny, Ranawaka APM Perera, Ronald LW Ko, Nagla Hassan, Basma Elsokary, Lotfi Allal, Ahmed Saad, Heba Sobhy, Pamela P. McKenzie, Richard J. Webby, Malik Peiris, Mohamed A. Ali & Ghazi Kayali

42 Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil - Vinicius Ponzio, Yuan Chen, Anderson Messias Rodrigues, Jennifer L. Tenor, Dena L. Toffaletti, José Osmar Medina-Pestana

43 Detection of human parvovirus 4 DNA in the patients with acute encephalitis syndrome during seasonal outbreaks of the disease in Gorakhpur, India - Vidya A. Arankalle , Navin Srivastava, Komal P. Kushwaha, Agnibha Sen, Ashwini Y. Ramdasi, Priyanka A. Patel, Sumeet Kuthe, Bangari Haldipur, Gajanan N Sakpal, Kavita S. Lole & Nilesh B Ingle

44 Simultaneous outbreaks of respiratory disease in wild chimpanzees caused by distinct viruses of human origin - Jacob D. Negrey , Rachna B. Reddy, Erik J. Scully, Sarah Phillips-Garcia, Leah A. Owens, Kevin E. Langergraber, John C. Mitani, Melissa Emery Thompson, Richard W. Wrangham, Martin N. Muller, Emily Otali, Zarin Machanda, David Hyeroba, Kristine A. Grindle, Tressa E. Pappas, Ann C. Palmenberg, James E. Gern & Tony L. Goldberg

45 Cross-reactive antibodies binding to H4 hemagglutinin protect against a lethal H4N6 influenza virus challenge in the mouse model - Fatima Amanat , Philip Meade, Shirin Strohmeier & Florian Krammer

46 Immunization with whole cell but not acellular pertussis vaccines primes CD4 TRM cells that sustain protective immunity against nasal colonization with Bordetella pertussis - Mieszko M. Wilk, Lisa Borkner, Alicja Misiak, Lucy Curham, Aideen C. Allen & Kingston H. G. Mills

47 Evidence of exposure and human seroconversion during an outbreak of avian influenza A(H5N1) among poultry in Cameroon - Chavely Gwladys Monamele , Phalla Y., Erik Albert Karlsson, Marie-Astrid Vernet, Abel Wade, Marie-Claire Assoumou Okomo, Aristide Stéphane Abah Abah, Sokhoun Yann, Georges Alain Mballa Etoundi, Njankouo Ripa Mohamadou, Jean-Marc Feussom, Sreyviseth Horm, Paul Francis Horwood, Sowath Ly, Richard Njouom & Philippe Dussart

48 Differential effects of depot medroxyprogesterone acetate administration on vaginal microbiome in Hispanic White and Black women - Liying Yang, Yuhan Hao, Jiyuan Hu, Dervla Kelly, Huilin Li, Stuart Brown, Carley Tasker, Natalie E. Roche, Theresa L. Chang & Zhiheng Pei

49 Tox-positive Corynebacterium ulcerans in hedgehogs, Germany* - Anja Berger , Alexandra Dangel, Martin Peters, Kristin Mühldorfer, Silke Braune, Tobias Eisenberg, Claudia A. Szentiks, Jörg Rau, Regina Konrad, Stefan Hörmansdorfer, Nikolaus Ackermann & Andreas Sing

50 Haemagogus leucocelaenus and Haemagogus janthinomys are the primary vectors in the major yellow fever outbreak in Brazil, 2016–2018 - Filipe Vieira Santos de Abreu, Ieda Pereira Ribeiro, Anielly Ferreira-de-Brito, Alexandre Araujo Cunha dos Santos, Rafaella Moraes de Miranda, Iule de Souza Bonelly, Maycon Sebastião Alberto Santos Neves, Maria Ignez Bersot, Taissa Pereira dos Santos, Marcelo Quintela Gomes, José Luis da Silva, Alessandro Pecego Martins Romano, Roberta Gomes Carvalho, Rodrigo Fabiano do Carmo Said, Mario Sergio Ribeiro, Roberto da Costa Laperrière, Eduardo Oyama Lins Fonseca, Aloísio Falqueto, Christophe Paupy, Anna-Bella Failloux, Sara Moutailler, Marcia Gonçalves de Castro, Mariela Martínez Gómez, Monique de Albuquerque Motta, Myrna Cristina Bonaldo & Ricardo Lourenço-de-Oliveira

51 Infectivity of Zika virus on primary cells support tree shrew as animal model - Li Zhang, Zhi-Li Shen, Yue Feng, Dao-Qun Li, Na-Na Zhang, Yong-Qiang Deng, Xiao-Peng Qi, Xiao-Mei Sun, Jie-Jie Dai, Chun-Guang Yang, Zi-Feng Yang, Cheng-Feng Qin & Xue-Shan Xia

52 Multi-omics comparisons of p-aminosalicylic acid (PAS) resistance in folC mutated and un-mutated Mycobacterium tuberculosis strains - Wenjing Wei, Huimin Yan, Jiao Zhao, Haicheng Li, Zhenyan Li, Huixin Guo, Xuezhi Wang, Ying Zhou, Xiaoli Zhang, Jincheng Zeng, Tao Chen & Lin Zhou

53 Genetic diversity and host adaptation of avian H5N1 influenza viruses during human infection - Matthijs R.A. Welkers, Hana A. Pawestri, Judy M. Fonville, Ondri D. Sampurno, Maarten Pater, Melle Holwerda, Alvin X. Han, Colin A. Russell, Rienk E. Jeeninga, Vivi Setiawaty, Menno D. de Jong & Dirk Eggink

54 Nipah pseudovirus system enables evaluation of vaccines in vitro and in vivo using non-BSL-4 facilities - Jianhui Nie, Lin Liu, Qing Wang, Ruifeng Chen, Tingting Ning, Qiang Liu, Weijin Huang & Youchun Wang

55 Exonic sequencing identifies TLR1 genetic variation associated with mortality in Thais with melioidosis - Shelton W. Wright, Viriya Hantrakun, Wirongrong Chierakul, Prapit Teparrukkul, Narisara Chantratita, Direk Limmathurotsakul & T. Eoin West

56 The QP509L and Q706L superfamily II RNA helicases of African swine fever virus are required for viral replication, having non-redundant activities - Ferdinando B. Freitas, Gonçalo Frouco, Carlos Martins & Fernando Ferreira

57 Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons - Wenshuo Zhou, Michael Woodson, Michael B. Sherman, Girish Neelakanta & Hameeda Sultana

58 Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding - Jimmy Chun Cheong Lai, Herath M. T. K. Karunarathna, Ho Him Wong, Joseph S. M. Peiris & John M. Nicholls

59 Prospective case-control analysis of the aetiologies of acute undifferentiated fever in Vietnam - Nhiem Le-Viet, Viet-Nho Le, Hai Chung, Duc-Tuan Phan, Quang-Duong Phan, Thanh-Van Cao, Cédric Abat, Didier Raoult & Philippe Parola

60 Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice - Yan Liu, Yi Zhou, Xiaodong Li, Ming Niu, Rongjuan Chen, Jinman Shao, Lanlan Si, Dan Luo, Yayun Lin, Le Li, Kai Zhang, Xiaohe Xiao, Zhihui Xu, Min Liu, Mengji Lu, Fabien Zoulim & Dongping Xu

61 Effects of cotrimoxazole prophylaxis on Talaromyces marneffei infection in HIV/AIDS patients receiving antiretroviral therapy: a retrospective cohort study - Junjun Jiang, Fengxiang Qin, Sirun Meng, Eric J. Nehl, Jinping Huang, Yanfen Liu, Jun Zou, Wenyi Dong, Jiegang Huang, Hui Chen, Ning Zang, Bingyu Liang, Chuanyi Ning, Yanyan Liao, Chaolian Luo, Huifang Liu, Xin Liu, Jian Wang, Oulu Zhou, Thuy Le, Li Ye, Fengyao Wu & Hao Liang

62 Host-dependence of in vitro reassortment dynamics among the Sathuperi and Shamonda Simbuviruses - Damien Coupeau, Calixte Bayrou, Pierre Baillieux, Axel Marichal, Anne-Cécile Lenaerts, Céline Caty, Laetitia Wiggers, Nathalie Kirschvink, Daniel Desmecht & Benoît Muylkens

63 Evolution and transmission of a conjugative plasmid encoding both ciprofloxacin and ceftriaxone resistance in Salmonella - Kaichao Chen, Edward Wai Chi Chan & Sheng Chen

64 Serum anti-neuraminidase antibody responses in human influenza A(H1N1)pdm09 virus infections - Herath M. T. K. Karunarathna, Ranawaka A. P. M. Perera, Vicky J. Fang, Hui-ling Yen, Benjamin John Cowling & Malik Peiris

65 Cultivation of the causative agent of human neoehrlichiosis from clinical isolates identifies vascular endothelium as a target of infection - Linda Wass, Anna Grankvist, Lesley Bell-Sakyi, Malin Bergström, Erik Ulfhammer, Christine Lingblom & Christine Wennerås

66 Cell surface α2,3-linked sialic acid facilitates Zika virus internalization - Chee Wah Tan, Catherine Hong Huan Hor, Swee Sen Kwek, Han Kang Tee, I-Ching Sam, Eyleen L. K. Goh, Eng Eong Ooi, Yoke Fun Chan & Lin-Fa Wang

67 Replication and virulence in pigs of the first African swine fever virus isolated in China - Dongming Zhao, Renqiang Liu, Xianfeng Zhang, Fang Li, Jingfei Wang, Jiwen Zhang, Xing Liu, Lulu Wang, Jiaoer Zhang, Xinzhou Wu, Yuntao Guan, Weiye Chen, Xijun Wang, Xijun He & Zhigao Bu

68 Elevated pulmonary tuberculosis biomarker miR-423-5p plays critical role in the occurrence of active TB by inhibiting autophagosome-lysosome fusion - Huihui Tu, Su Yang, Tingting Jiang, Liliang Wei, Liying Shi, Changming Liu, Chong Wang, Huai Huang, Yuting Hu, Zhongliang Chen, Jing Chen, Zhongjie Li & Jicheng Li

69 Genomic epidemiology of erythromycin-resistant Bordetella pertussis in China - Zheng Xu, Zengguo Wang, Yang Luan, Yarong Li, Xiaoguai Liu, Xiaokang Peng, Sophie Octavia, Michael Payne & Ruiting Lan

70 Decreasing methicillin-resistant Staphylococcus aureus (MRSA) infections is attributable to the disappearance of predominant MRSA ST239 clones, Shanghai, 2008–2017 - Yingxin Dai, Junlan Liu, Wei Guo, Hongwei Meng, Qian Huang, Lei He, Qianqian Gao, Huiying Lv, Yao Liu, Yanan Wang, Hua Wang, Qian Liu & Min Li

71 Low pathogenic avian influenza (H7N6) virus causing an outbreak in commercial Turkey farms in Chile - Pedro Jimenez-Bluhm, Nicolas Bravo-Vasquez, Mia K. Torchetti, Mary L. Killian, Brandi Livingston, Jose Herrera, Mauricio Fuentes, Stacey Schultz-Cherry & Christopher Hamilton-West

72 Cumulative acquisition of pathogenicity islands has shaped virulence potential and contributed to the emergence of LEE-negative Shiga toxin-producing Escherichia coli strains - David Arturo Montero, Felipe Del Canto, Juliana Velasco, Rocío Colello, Nora Lia Padola, Juan Carlos Salazar, Carla San Martin, Angel Oñate, Jorge Blanco, David A. Rasko, Carmen Contreras, Jose Luis Puente, Flemming Scheutz, Eelco Franz & Roberto M. Vidal

73 The role of ArlRS in regulating oxacillin susceptibility in methicillin-resistant Staphylococcus aureus indicates it is a potential target for antimicrobial resistance breakers - Jinna Bai, Xiaoyi Zhu, Keqing Zhao, Yingjie Yan, Tao Xu, Jiaxue Wang, Jinxing Zheng, Wei Huang, Le Shi, Yongpeng Shang, Zhihui Lv, Xiaofei Wang, Yang Wu & Di Qu

74 Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein - Ivy Widjaja, Chunyan Wang, Rien van Haperen, Javier Gutiérrez-Álvarez, Brenda van Dieren, Nisreen M.A. Okba, V. Stalin Raj, Wentao Li, Raul Fernandez-Delgado, Frank Grosveld, Frank J. M. van Kuppeveld, Bart L. Haagmans, Luis Enjuanes, Dubravka Drabek & Berend-Jan Bosch

75 Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing - Chi-Ching Tsang, James Y. M. Tang, Ka-Fai Chan, Chun-Yi Lee, Jasper F. W. Chan, Antonio H. Y. Ngan, Mei Cheung, Eunice C. L. Lau, Xin Li, Ricky H. Y. Ng, Christopher K. C. Lai, Kitty S. C. Fung, Susanna K. P. Lau & Patrick C. Y. Woo

76 Human MxA is a potent interspecies barrier for the novel bat-derived influenza A-like virus H18N11 - Kevin Ciminski, Johanna Pulvermüller, Julia Adam & Martin Schwemmle

77 Detection and characterization of tigecycline heteroresistance in E. cloacae: clinical and microbiological findings - Hang Liu, Xiaojiong Jia, Hua Zou, Shan Sun, Shuang Li, Yonghong Wang & Yun Xia

78 Genetic and biochemical characterizations of Zika virus NS2A protein - Xianwen Zhang, Xuping Xie, Jing Zou, Hongjie Xia, Chao Shan, Xinwen Chen & Pei-Yong Shi

79 The evolution of Bordetella pertussis has selected for mutations of acr that lead to sensitivity to hydrophobic molecules and fatty acids - Iain MacArthur, Thomas Belcher, Jerry D. King, Vasantha Ramasamy, Munirah Alhammadi & Andrew Preston

80 Detection of dicistroviruses RNA in blood of febrile Tanzanian childre - Samuel Cordey, Florian Laubscher, Mary-Anne Hartley, Thomas Junier, Francisco J. Pérez-Rodriguez, Kristina Keitel, Gael Vieille, Josephine Samaka, Tarsis Mlaganile, Frank Kagoro, Noémie Boillat-Blanco, Zainab Mbarack, Mylène Docquier, Francisco Brito, Daniel Eibach, Jürgen May, Peter Sothmann, Cassandra Aldrich, John Lusingu, Caroline Tapparel, Valérie D’Acremont & Laurent Kaiser

81 Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models - Nereida Jiménez de Oya, William P. Esler, Kim Huard, Ayman F. El-Kattan, Georgios Karamanlidis, Ana-Belén Blázquez, Priscila Ramos-Ibeas, Estela Escribano-Romero, Andrés Louloudes-Lázaro, Josefina Casas, Francisco Sobrino, Kyle Hoehn, David E. James, Alfonso Gutiérrez-Adán, Juan-Carlos Saiz & Miguel A. Martín-Acebes

82 Evaluation of rodent control to fight Lassa fever based on field data and mathematical modelling - Joachim Mariën, Benny Borremans, Fodé Kourouma, Jatta Baforday, Toni Rieger, Stephan Günther, N’Faly Magassouba, Herwig Leirs & Elisabeth Fichet-Calvet

83 Continuing evolution of highly pathogenic H5N1 viruses in Bangladeshi live poultry markets - Subrata Barman, Jasmine C. M. Turner, M. Kamrul Hasan, Sharmin Akhtar, Rabeh El-Shesheny, John Franks, David Walker, Patrick Seiler, Kimberly Friedman, Lisa Kercher, Trushar Jeevan, Pamela McKenzie, Richard J Webby, Robert G Webster & Mohammed M Feeroz \

84 SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection - Wing-Yu Lui, Chun-Kit Yuen, Can Li, Wan Man Wong, Pak-Yin Lui, Chi-Ho Lin, Kwok-Hung Chan, Hanjun Zhao, Honglin Chen, Kelvin K. W. To, Anna J. X Zhang, Kwok-Yung Yuen & Kin-Hang Kok

85 Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland - Teemu Smura,Elina Tonteri, Anu Jääskeläinen, Gabriel von Troil, Suvi Kuivanen, Otso Huitu, Lauri Kareinen, Joni Uusitalo, Ruut Uusitalo, Tuula Hannila-Handelberg, Liina Voutilainen, Simo Nikkari, Tarja Sironen, Jussi Sane, Janne Castrén & Olli Vapalahti

86 PCV3-associated disease in the United States swine herd - Bailey Arruda, Pablo Piñeyro, Rachel Derscheid, Ben Hause, Emily Byers, Kate Dion, Duane Long, Chris Sievers, Jon Tangen, Todd Williams & Kent Schwartz show less

87 Transmission potential of African, Asian and American Zika virus strains by Aedes aegypti and Culex quinquefasciatus from Guadeloupe (French West Indies) - Lyza Hery, Antoine Boullis, Christelle Delannay & Anubis Vega-Rúa

88 Subinhibitory concentrations of Honokiol reduce α-Hemolysin (Hla) secretion by Staphylococcus aureus and the Hla-induced inflammatory response by inactivating the NLRP3 inflammasome - Na Guo, Zuojia Liu, Zhiqiang Yan, Zonghui Liu, Kun Hao, Chuanbo Liu & Jin Wang

89 Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection* - Danielle R. Adney, Michael Letko, Izabela K. Ragan, Dana Scott, Neeltje van Doremalen, Richard A. Bowen & Vincent J. Munster

90 Robust in vitro assay for analyzing the neutralization activity of serum specimens against hepatitis B virus - Ya-Li Zhang, Ying Gao, Jia-Li Cao, Jing-Hua Zhao, Tian-Ying Zhang, Chuan-Lai Yang, Hua-Long Xiong, Ying-Bin Wang, Shan-Hai Ou, Tong Cheng, Chang-Rong Chen, Quan Yuan & Ning-Shao Xia

91 Enterohemorrhagic Escherichia coli Tir inhibits TAK1 activation and mediates immune evasion - Ruixue Zhou, Zijuan Chen, Doudou Hao, Yu Wang, Yihua Zhang, Xianfu Yi, Liang-Dong Lyu, Haipeng Liu, Quanming Zou, Yiwei Chu, Baoxue Ge & Dapeng Yan

92 Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model - Xuefeng Niu, Lingzhai Zhao, Linbing Qu, Zhipeng Yao, Fan Zhang, Qihong Yan, Shengnan Zhang, Renshan Liang, Peihai Chen, Jia Luo, Wei Xu, Huibin Lv, Xinglong Liu, Hui Lei, Changhua Yi, Pingchao Li, Qian Wang, Yang Wang, Lei Yu, Xiaoyan Zhang, L. Aubrey Bryan, Edgar Davidson, j. Benjamin Doranz, Liqiang Feng, Weiqi Pan, Fuchun Zhang & Ling Chen

93 Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection - Wenxu Jia, Rudragouda Channappanavar, Chao Zhang, Mingxi Li, Haixia Zhou, Shuyuan Zhang, Panpan Zhou, Jiuyang Xu, Sisi Shan, Xuanling Shi, Xinquan Wang, Jincun Zhao, Dongming Zhou, Stanley Perlman & Linqi Zhang

94 Endophilin-A2-mediated endocytic pathway is critical for enterovirus 71 entry into caco-2 cells - Sheng-Lin Chen, Yan-Gang Liu, Yong-Tao Zhou, Ping Zhao, Hao Ren, Man Xiao, Yong-Zhe Zhu & Zhong-Tian Qi

95 Serological evidence and experimental infection of cynomolgus macaques with pteropine orthoreovirus reveal monkeys as potential hosts for transmission to humans - Chee Wah Tan, Kevin Wittwer, Xiao Fang Lim, Anna Uehara, Shailendra Mani, Lin-Fa Wang & Danielle E. Anderson

96 Francisella tularensis: FupA mutation contributes to fluoroquinolone resistance by increasing vesicle secretion and biofilm formation - Claire Siebert, Helena Lindgren, Sabrina Ferré, Corinne Villers, Sandrine Boisset, Julien Perard, Anders Sjöstedt, Max Maurin, Céline Brochier-Armanet, Yohann Couté & Patricia Renesto

97 Comparative genomics and genome biology of Campylobacter showae - Tiffany Hsu, Matthew R. Gemmell, Eric A. Franzosa, Susan Berry, Indrani Mukhopadhya, Richard Hansen, Monia Michaud, Hans Nielsen, William G. Miller, Henrik Nielsen, Mona Bajaj-Elliott, Curtis Huttenhower, Wendy S. Garrett & Georgina L. Hold

98 Transmission of ciprofloxacin resistance in Salmonella mediated by a novel type of conjugative helper plasmids - Kaichao Chen, Ning Dong, Edward Wai-Chi Chan & Sheng Chen

99 Detection and characterization of an emerging type of Babesia sp. similar to Babesia motasi for the first case of human babesiosis and ticks in Korea - Sung-Hee Hong, Seong-Yoon Kim, Bong Goo Song, Jong Yul Roh, Chong Rae Cho, Chul-Nam Kim, Tae-Hyun Um, Yee Gyung Kwak, Shin-Hyeong Cho & Sang-Eun Lee

100 Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection - Ying Yan, Lena Allweiss, Danli Yang, Jingting Kang, Jianwen Wang, Xiangjun Qian, Ting Zhang, Hui Liu, Lu Wang, Shuhong Liu, Jianhua Sui, Xiangmei Chen, Maura Dandri, Jingmin Zhao & Fengmin Lu

101 Cisplatin protects mice from challenge of Cryptococcus neoformans by targeting the Prp8 intein - Zhong Li, Bin Fu, Cathleen M. Green, Binbin Liu, Jing Zhang, Yuekun Lang, Sudha Chaturvedi, Marlene Belfort, Guojian Liao & Hongmin Li

102 The scrub typhus in mainland China: spatiotemporal expansion and risk prediction underpinned by complex factors - Hongwu Yao, Yixing Wang, Xianmiao Mi, Ye Sun, Kun Liu, Xinlou Li, Xiang Ren, Mengjie Geng, Yang Yang, Liping Wang, Wei Liu & Liqun Fang

103 Identification of a novel alphavirus related to the encephalitis complexes circulating in southern Brazil - Marcel Kruchelski Tschá, Andreia Akemi Suzukawa, Tiago Gräf, Laercio Dante Stein Piancini, Allan Martins da Silva, Helisson Faoro, Irina Nastassja Riediger, Lia Carolina Medeiros, Pryscilla Fanini Wowk, Camila Zanluca & Claudia Nunes Duarte dos Santos

104 Vibrio vulnificus RtxA1 cytotoxin targets filamin A to regulate PAK1- and MAPK-dependent cytoskeleton reorganization and cell death - Rui Hong Guo, Young Jun Im, Soo Im Shin, Kwangjoon Jeong, Joon Haeng Rhee & Young Ran Kim

105 Immunization with a recombinant antigen composed of conserved blocks from TSA56 provides broad genotype protection against scrub typhus - Hong-Il Kim, Na-Young Ha, Gwanghun Kim, Chan-Ki Min, Yuri Kim, Nguyen Thi Hai Yen, Myung-Sik Choi & Nam-Hyuk Cho

106 The native European Aedes geniculatus mosquito species can transmit chikungunya virus - Jorian Prudhomme, Albin Fontaine, Guillaume Lacour, Jean-Charles Gantier, Laure Diancourt, Enkelejda Velo, Silva Bino, Paul Reiter & Aurélien Mercier

107 Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice - Wenfei Zhu, Zhaomin Feng, Yongkun Chen, Lei Yang, Jia Liu, Xiyan Li, Suli Liu, Lijuan Zhou, Hejiang Wei, Rongbao Gao, Dayan Wang & Yuelong Shu

108 Zika virus differentially infects human neural progenitor cells according to their state of differentiation and dysregulates neurogenesis through the Notch pathway - Pauline Ferraris, Marielle Cochet, Rodolphe Hamel, Ivan Gladwyn-Ng, Christian Alfano, Fodé Diop, Déborah Garcia, Loïc Talignani, Claudia N. Montero-Menei, Antoine Nougairède, Hans Yssel, Laurent Nguyen, Muriel Coulpier & Dorothée Missé

109 Characterization of swine-origin H1N1 canine influenza viruses - Guojun Wang, Luiz Gustavo dos Anjos Borges, Daniel Stadlbauer, Irene Ramos, Maria C. Bermúdez González, Jianqiao He, Yangbao Ding, Zuzhang Wei, Kang Ouyang, Weijian Huang, Viviana Simon, Ana Fernandez-Sesma, Florian Krammer, Martha I. Nelson, Ying Chen & Adolfo García-Sastre

110 Comprehensive subspecies identification of 175 nontuberculous mycobacteria species based on 7547 genomic profiles - Yuki Matsumoto, Takeshi Kinjo, Daisuke Motooka, Daijiro Nabeya, Nicolas Jung, Kohei Uechi, Toshihiro Horii, Tetsuya Iida, Jiro Fujita & Shota Nakamura

111 Target-independent high-throughput sequencing methods provide evidence that already known human viral pathogens play a main role in respiratory infections with unexplained etiology - Unai Pérez-Sautu, Michael Ross Wiley, María Iglesias-Caballero, Francisco Pozo, Karla Prieto, Joseph Alex Chitty, María Luz García-García, Cristina Calvo, Inmaculada Casas & Gustavo Palacios

112 Hepatitis E-related adverse pregnancy outcomes and their prevention by hepatitis E vaccine in a rabbit model - Manyu Li, Shuangshuang Li, Qiyu He, Zhaochao Liang, Lin Wang, Qianhui Wang & Ling Wang

113 Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence - Liang Sun, Aloys Tijsma, Carmen Mirabelli, Jim Baggen, Maryam Wahedi, David Franco, Armando De Palma, Pieter Leyssen, Erik Verbeken, Frank J. M. van Kuppeveld, Johan Neyts & Hendrik Jan Thibaut

114 Chimpanzee adenoviral vector prime-boost regimen elicits potent immune responses against Ebola virus in mice and rhesus macaques - Xi Yang, Xiang Wang, Yufeng Song, Ping Zhou, Dapeng Li, Chao Zhang, Xia Jin, Zhong Huang & Dongming Zhou

115 The African strain of Zika virus causes more severe in utero infection than Asian strain in a porcine fetal transmission model - Daniel Udenze, Ivan Trus, Nathalie Berube, Volker Gerdts & Uladzimir Karniychuk

116 Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models - Nancy M. Cladel, Pengfei Jiang, Jingwei J. Li, Xuwen Peng, Timothy K. Cooper, Vladimir Majerciak, Karla K. Balogh, Thomas J. Meyer, Sarah A. Brendle, Lynn R. Budgeon, Debra A. Shearer, Regina Munden, Maggie Cam, Raghavan Vallur, Neil D. Christensen, Zhi-Ming Zheng & Jiafen Hu

117 Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity - Natalie D. Collins, Steven G. Widen, Li Li, Daniele M. Swetnam, Pei-Yong Shi, Robert B. Tesh & Vanessa V. Sarathy show less

118 Mapping histoplasmosis in South East Asia – implications for diagnosis in AIDS - Jacob Baker, Findra Setianingrum, Retno Wahyuningsih & David W. Denning

119 Pregnancy level of estradiol attenuated virus-specific humoral immune response in H5N1-infected female mice despite inducing anti-inflammatory protection - Courtney L. Finch, Anding Zhang, Martina Kosikova, Toshiaki Kawano, Marcela F. Pasetti, Zhiping Ye, Jill R. Ascher & Hang Xie

120 Co-circulation and persistence of multiple A/H3N2 influenza variants in China - Weifeng Shi, Changwen Ke, Shisong Fang, Juan Li, Hao Song, Xiyan Li, Tao Hu, Jie Wu, Tao Chen, Lina Yi, Yingchao Song, Xin Wang, Weijia Xing, Weijuan Huang, Hong Xiao, Lijun Liang, Bo Peng, Weihua Wu, Hui Liu, William J. Liu, Edward C. Holmes, George F. Gao & Dayan Wang

121 A rapid diagnostic test for human Visceral Leishmaniasis using novel Leishmania antigens in a Laser Direct-Write Lateral Flow Device - Maria Victoria Humbert, Lourena Emanuele Costa, Ioannis Katis, Fernanda Fonseca Ramos, Amanda Sanchéz Machado, Collin Sones, Eduardo Antonio Ferraz Coelho & Myron Christodoulides

122 Combining sequencing approaches to fully resolve a carbapenemase-encoding megaplasmid in a Pseudomonas shirazica clinical strain - João Botelho, Cédric Lood, Sally R. Partridge, Vera van Noort, Rob Lavigne, Filipa Grosso & Luísa Peixe

123 Carriage and potential long distance transmission of Listeria monocytogenes by migratory black-headed gulls in Dianchi Lake, Kunming - Lin Gan, Xiaolong Cao, Yan Wang, Yiqian Wang, Huaying Jiang, Ruiting Lan, Jianguo Xu & Changyun Ye

124 A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue - Ethel-Michele de Villiers, Karin Gunst, Deblina Chakraborty, Claudia Ernst, Timo Bund & Harald zur Hausen

125 Comprehensive analysis of the lysine acetylome in Aeromonas hydrophila reveals cross-talk between lysine acetylation and succinylation in LuxS - Lina Sun, Zujie Yao, Zhuang Guo, Lishan Zhang, Yuqian Wang, Ranran Mao, Yuexu Lin, Yuying Fu & Xiangmin Lin

126 Metabonomics on Candida albicans indicate the excessive H3K56ac is involved in the antifungal activity of Shikonin - ZeBin Liao, ZhenYu Zhu, Ling Li, Liang Wang, Hui Wang, YuanYing Jiang & YingYing Cao

127 PmtA functions as a ferrous iron and cobalt efflux pump in Streptococcus suis - Chengkun Zheng, Mengdie Jia, Miaomiao Gao, Tianyu Lu, Lingzhi Li & Pingping Zhou

128 Evolution and biological significance of flaviviral elements in the genome of the arboviral vector Aedes albopictus - Vincent Houé, Gaelle Gabiane, Catherine Dauga, Marie Suez, Yoann Madec, Laurence Mousson, Michele Marconcini, Pei-Shi Yen, Xavier de Lamballerie, Mariangela Bonizzoni & Anna-Bella Failloux

129 H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets - Lizheng Guan, Jianzhong Shi, Xingtian Kong, Shujie Ma, Yaping Zhang, Xin Yin, Xijun He, Liling Liu, Yasuo Suzuki, Chengjun Li, Guohua Deng & Hualan Chen

130 Viral metagenomics updated the prevalence of human papillomavirus types in anogenital warts - Hui Xu, Yu Ling, Yuan Xi, Hong Ma, Hao Wang, Hui-Min Hu, Qi Liu, Yu-Mei Li, Xu-Tao Deng, Shi-Xing Yang, Eric Delwart & Wen Zhang

131 Marburg virus regulates the IRE1/XBP1-dependent unfolded protein response to ensure efficient viral replication - Cornelius Rohde, Stephan Becker & Verena Krähling

132 Synchronous shedding of multiple bat paramyxoviruses coincides with peak periods of Hendra virus spillover - Alison J. Peel, Konstans Wells, John Giles, Victoria Boyd, Amy Burroughs, Daniel Edson, Michelle L. Baker, Hume Field, Lin-Fa Wang, Hamish McCallum, Raina K. Plowright & Nicholas Clark

133 Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs - Carola Dreier, Patricia Resa-Infante, Swantje Thiele, Stephanie Stanelle-Bertram, Kerstin Walendy-Gnirß, Thomas Speiseder

134 Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains - Lu Zhang, Le Chang, Syria Laperche, Huimin Ji, Junpeng Zhao, Xinyi Jiang, Lunan Wang & Daniel Candotti

135 Host factor SMYD3 is recruited by Ebola virus nucleoprotein to facilitate viral mRNA transcription - Jingliang Chen, Zhangping He, Yaochang Yuan, Feng Huang, Baohong Luo, Jianhua Zhang, Ting Pan, Hui Zhang & Junsong Zhang

136 CRISPR-based rapid and ultra-sensitive diagnostic test for Mycobacterium tuberculosis - Jing-Wen Ai, Xian Zhou, Teng Xu, Minling Yang, Yuanyuan Chen, Gui-Qing He, Ningp Pan, Yuwei Cai, Yongjun Li, Xiaorui Wang, Hang Su, Ting Wang, Weiqi Zeng & Wen-Hong Zhang

137 Active surveillance and genetic evolution of avian influenza viruses in Egypt, 2016–2018 - Ahmed Kandeil, Joseph T. Hicks, Sean G. Young, Ahmed N. El Taweel, Ahmed S. Kayed, Yassmin Moatasim, Omnia Kutkat, Ola Bagato, Pamela P. McKenzie, Zhipeng Cai, Rebecca Badra, Mohamed Kutkat, Justin Bahl, Richard J. Webby, Ghazi Kayali & Mohamed A. Ali

138 An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species - Wendy K. Jo, Cornelis van Elk, Marco van de Bildt, Peter van Run, Monique Petry, Sonja T. Jesse, Klaus Jung, Martin Ludlow, Thijs Kuiken & Albert Osterhaus

139 Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation - Huijing Chen, Yi Zhang, Shuangshuang Ye, Qiong Wu, Youfen Lin, Kaiqin Sheng, Wannan Chen, Xinjian Lin & Xu Lin

140 The cytochrome d oxidase complex regulated by fexA is an Achilles' heel in the in vivo survival of Vibrio vulnificus - Wenzhi Tan, Kwangjoon Jeong, Raghunath Pendru, Sao Puth, Seol Hee Hong, Shee Eun Lee & Joon Haeng Rhee

141 Genomic epidemiology of Iranian Bordetella pertussis: 50 years after the implementation of whole cell vaccine - Azadeh Safarchi, Sophie Octavia, Vajihe Sadat Nikbin, Masoumeh Nakhost Lotfi, Seyed Mohsen Zahraei, Chin Yen Tay, Binit Lamichhane, Fereshteh Shahcheraghi & Ruiting Lan

142 MDCK-B4GalNT2 cells disclose a α2,3-sialic acid requirement for the 2009 pandemic H1N1 A/California/04/2009 and NA aid entry of A/WSN/33 - Ho Him Wong, Kevin Fung & John M. Nicholls

143 Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018 - Rubén González-Sanz, Irene Taravillo, Jordi Reina, Ana Navascués, Antonio Moreno-Docón, Maitane Aranzamendi, María Pilar Romero, Margarita del Cuerpo, Carmen Pérez-González, Sonia Pérez-Castro, Almudena Otero & María Cabrerizo

144 A neonatal murine model of coxsackievirus A4 infection for evaluation of vaccines and antiviral drugs - Zhenjie Zhang, Xingcheng Zhang, Michael J. Carr, Hong Zhou, Juan Li, Shaoqiong Liu, Tao Liu, Weijia Xing & Weifeng Shi

145 Novel reassortant of H1N1 swine influenza virus detected in pig population in Russia - Ivan Sobolev, Olga Kurskaya, Sergey Leonov, Marsel Kabilov, Tatyana Alikina, Alexander Alekseev, Yuriy Yushkov, Takehiko Saito, Yuko Uchida, Junki Mine, Alexander Shestopalov & Kirill Sharshov

146 Insights into species-specific regulation of ANP32A on the mammalian-restricted influenza virus polymerase activity - Zhenwei Bi, Hongliu Ye, Xingbo Wang, An Fang, Tianqi Yu, Liping Yan & Jiyong Zhou

147 Molecular surveillance of antimicrobial resistance and transmission pattern of Mycobacterium leprae in Chinese leprosy patients - Santosh Chokkakula, Zhiming Chen, Le Wang, Haiqin Jiang, Yanqing Chen, Ying Shi, Wenyue Zhang, Wei Gao, Jun Yang, Jinlan Li, Xiong Li, Tiejun Shui, Jun He, Limei Shen, Jie Liu, De Wang, Hao Wang, Huan Chen, Yanfei Kuang, Bin Li, Ziyi Chen, Aiping Wu, Meiwen Yu, Liangbin Yan, Naveen Chandra Suryadevara, Varalakshmi Vissa, Weida Liu & Hongsheng Wang

148 Demographic and clinical characteristics of chikungunya patients from six Colombian cities, 2014–2015 - Juan C. Rueda, Ana M. Santos, Jose-Ignacio Angarita, Rodrigo B. Giraldo, Eugenia-Lucia Saldarriaga, Jesús Giovanny Ballesteros Muñoz

149 The Nsp12-coding region of type 2 PRRSV is required for viral subgenomic mRNA synthesis - Tong-Yun Wang, Qiong-Qiong Fang, Feng Cong, Yong-Gang Liu, Hai-Ming Wang, Hong-Liang Zhang, Zhi-Jun Tian, Yan-Dong Tang & Xue-Hui Cai

150 GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus - Danying Chen, Zhifei Hou, Dong Jiang, Mei Zheng, Guoli Li, Yue Zhang, Rui Li, Hanxin Lin, Jinhong Chang, Hui Zeng, Ju-Tao Guo & Xuesen Zhao

151 Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels - Wei Zhang, Xiao-Shuang Zheng, Bernard Agwanda, Sheila Ommeh, Kai Zhao, Jacqueline Lichoti, Ning Wang, Jing Chen, Bei Li, Xing-Lou Yang, Shailendra Mani, Kisa-Juma Ngeiywa, Yan Zhu, Ben Hu, Samson Omondi Onyuok, Bing Yan, Danielle E. Anderson, Lin-Fa Wang, Peng Zhou & Zheng-Li Shi

152 Human infection with a novel reassortant Eurasian-avian lineage swine H1N1 virus in northern China - Xiaoyan Li, Liru Guo, Caixia Liu, Yanhui Cheng, Mei Kong, Lei Yang, Zhichao Zhuang, Jia Liu, Ming Zou, Xiaochun Dong, Xu Su & Qing Gu

153 Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region* - Yun Luo, Elaine Cheong, Qiao Bian, Deirdre A. Collins, Julian Ye, Jeong Hwan Shin, Wing Cheong Yam, Tohru Takata, Xiaojun Song, Xianjun Wang, Mini Kamboj, Thomas Gottlieb, Jianmin Jiang, Thomas V. Riley, Yi-Wei Tang & Dazhi Jin

154 Keeping all secondary structures of the non-coding region in the circular genome of human bocavirus 2 is important for DNA replication and virus assembly, as revealed by three hetero-recombinant genomic clones - Linqing Zhao, Tao Wang, Yuan Qian, Jingdong Song, Runan Zhu, Liying Liu, Liping Jia & Huijin Dong

155 Visualization of chikungunya virus infection in vitro and in vivo - Hong-Lei Zhang, Hao-Long Dong, Ya-Nan Zhang, Lin-Lin Xu, Cheng-Lin Deng, Xiao-Feng Li, Xiao-Dan Li, Han-Qing Ye, Zhi-Ming Yuan, Cheng-Feng Qin & Bo Zhang

156 Antigenic variations of recent street rabies virus - Wenbo Wang, Jian Ma, Jianhui Nie, Jia Li, Shouchun Cao, Lan Wang, Chuanfei Yu, Weijin Huang, Yuhua Li, Yongxin Yu, Mifang Liang, Brett Zirkle, Xiaojiang S. Chen, Xuguang Li, Wei Kong & Youchun Wang

157 Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein - Jordi Rodon, Nisreen M. A. Okba, Nigeer Te, Brenda van Dieren, Berend-Jan Bosch, Albert Bensaid, Joaquim Segalés, Bart L. Haagmans & Júlia Vergara-Alert

158 Mechanisms underlying the virulence regulation of new Vibrio alginolyticus ncRNA Vvrr1 with a comparative proteomic analysis - Yanfei Zuo, Lingmin Zhao, Xiaojin Xu, Jiaonan Zhang, Jiaolin Zhang, Qingpi Yan & Lixing Huang

159 Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata - Xin Hou, Kelley R. Healey, Erika Shor, Milena Kordalewska, Cristina Jiménez Ortigosa, Padmaja Paderu, Meng Xiao, He Wang, Ying Zhao, Li-Yan Lin, Yan-Hai Zhang, Yong-Zhe Li, Ying-Chun Xu, David S. Perlin & Yanan Zhao

160 Potential of Aedes albopictus and Aedes aegypti (Diptera: Culicidae) to transmit yellow fever virus in urban areas in Central Africa - Basile Kamgan, Marie Vazeille, Aurélie P. Yougang, Armel N. Tedjou, Theodel A. Wilson-Bahun, Laurence Mousson, Charles S. Wondji & Anna-Bella Failloux

161 Structural basis of host ligand specificity change of GII porcine noroviruses from their closely related GII human noroviruses - Yang Yang, Ming Xia, Leyi Wang, Sahaana Arumugam, Yajing Wang, Xianjin Ou, Chenlong Wang, Xi Jiang, Ming Tan, Yutao Chen & Xuemei Li

162 Identification of a novel RhlI/R-PrrH-LasI/Phzc/PhzD signalling cascade and its implication in P. aeruginosa virulence - Yang Lu, Honglin Li, Jieying Pu, Qian Xiao, Chanjing Zhao, Yimei Cai, Yuyang Liu, Lina Wang, Youqiang Li, Bin Huang, Jianming Zeng & Cha Chen

163 Zika virus threshold determines transmission by European Aedes albopictus mosquitoes - Marie Vazeille, Yoann Madec, Laurence Mousson, Rachel Bellone, Hélène Barré-Cardi, Carla Alexandra Sousa, Davy Jiolle, André Yébakima, Xavier de Lamballerie & Anna-Bella Failloux

164 Dual activity of PNGM-1 pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases: a molecular and evolutionary study - Jung Hun Lee, Masayuki Takahashi, Jeong Ho Jeon, Lin-Woo Kang, Mineaki Seki, Kwang Seung Park, Myoung-Ki Hong, Yoon Sik Park, Tae Yeong Kim, Asad Mustafa Karim, Jung-Hyun Lee, Masayuki Nashimoto & Sang Hee Lee

165 The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj - Van-Thuan Hoang, Thi-Loi Dao, Tran Duc Anh Ly, Khadidja Belhouchat, Kamel Larbi Chaht, Jean Gaudart, Bakridine Mmadi Mrenda, Tassadit Drali, Saber Yezli, Badriah Alotaibi, Pierre-Edouard Fournier, Didier Raoult, Philippe Parola, Vincent Pommier de Santi & Philippe Gautret

166 Population dynamics and antigenic drift of Bordetella pertussis following whole cell vaccine replacement, Barcelona, Spain, 1986–2015 - Alba Mir-Cros, Albert Moreno-Mingorance, M. Teresa Martín-Gómez, Gema Codina, Thais Cornejo-Sánchez, Mireia Rajadell, Diego Van Esso, Carlos Rodrigo, Magda Campins, Mireia Jané, Tomàs Pumarola, Anna Fàbrega & Juan José González-López

167 Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection - Xinlin Liu, Jie Chen, Zhiping Wang, Daning Wang, Maozhou He, Ciying Qian, Shuo Song, Xin Chi, Zhibo Kong, Qingbing Zheng, Yingbin Wang, Hai Yu, Qinjian Zhao, Jun Zhang, Shaowei Li, Ying Gu & Ningshao Xia

168 Limited evolution of the yellow fever virus 17d in a mouse infection model - Dieudonné Buh Kum, Niraj Mishra, Bram Vrancken, Hendrik Jan Thibaut, Annelies Wilder-Smith, Philippe Lemey, Johan Neyts & Kai Dallmeier

169 The incidence and prevalence of hospital-acquired (carbapenem-resistant) Acinetobacter baumannii in Europe, Eastern Mediterranean and Africa: a systematic review and meta-analysis - Olaniyi Ayobami, Niklas Willrich, Thomas Harder, Iruka N. Okeke, Tim Eckmanns & Robby Markwart

170 Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities - Aline da Rocha Matos, Katharina Wunderlich, Sebastian Schloer, Klaus Schughart, Robert Geffers, Martine Seders, Marlous de Witt, Anmari Christersson, Rainer Wiewrodt, Karsten Wiebe, Peter Barth, Andreas Hocke, Stefan Hippenstiel, Katja Hönzke, Ulf Dittmer, Kathrin Sutter, Ursula Rescher, Svetlana Rodionycheva, Nicoletta Matera, Stephan Ludwig & Linda Brunotte

171 Transcriptional response to metal starvation in the emerging. pathogen Mycoplasma genitalium is mediated by Fur-dependent and –independent regulatory pathways - Carlos Martínez-Torró, Sergi Torres-Puig, Marta Monge, Lucía Sánchez-Alba, Miguel González-Martín, Marina Marcos-Silva, Alex Perálvarez-Marín, Francesc Canals, Enrique Querol, Jaume Piñol & Oscar Q. Pich

172 Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and. NS7 functions: a novel strategy for vaccine design - Mengjia Zhang, Wan Li, Peng Zhou, Dejian Liu, Rui Luo, Anan Jongkaewwattana & Qigai He

173 Clostridioides difficile infection in the Asia-Pacific region - Deirdre A. Collins, Kyung Mok Sohn, Yuan Wu, Kentaro Ouchi, Yoshikazu Ishii, Briony Elliott, Thomas V. Riley, Kazuhiro Tateda & for the Clostridioides difficile Asia-Pacific Study Group