Tuberculosis (TB)

Guest Editors:

  • Qian Gao (Shanghai Medical College, Fudan University, China)
  • Wenhong Zhang (Huashan Hospital, China)

tbEMI Special Topic-TB will focus on the characterization of TB which remains an unacceptable burden of human suffering and loss, overwhelmingly borne by poor and vulnerable people living in low- or middle-income countries. Progress in global TB control is, however, constrained by the lack of highly effective and widely accessible diagnostics, drugs and vaccines. EMI Special Topic-TB welcomes research reports and high quality reviews on the following areas of TB research: epidemiology, fundamental research, development of new diagnostics and biomarkers, development of new drugs and vaccines, and public health issues related to this important pathogen.

More articles to be added soon.

2013

Title: Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β

Authors: Mishra BB, Rathinam VA, Martens GW, Martinot AJ, Kornfeld H, Fitzgerald KA, Sassetti CM

Nat Immunol 2013 Jan;14(1):52-60. doi: 10.1038/ni.2474. LINK


2012

Title: The Role of Biomedical Research in Global Tuberculosis Control- Gaps and Challenges. A Perspective from the US

Authors: Christine F Sizemore, Amanda C Schleif, Jessica B Bernstein and Carole A Heilman

Emerg Microbes Infect 1: e9; doi:10.1038/emi.2012.21 LINK


Title: “ZS-MDR-TB” versus “ZR-MDR-TB”: Improving Treatment of MDR-TB by Identifying Pyrazinamide Susceptibility

Authors: Ying Zhang, Kwok Chiu Chang, Chi-Chiu Leung, Wing Wai Yew, Brigitte Gicquel, Dorothy Fallows, Gilla Kaplan, Richard E Chaisson and Wenhong Zhang

Emerg Microbes Infect 1: e5; doi:10.1038/emi.2012.18 LINK


Title: Tuberculosis Vaccine Research in China

Authors: Douglas B Lowrie

Emerg Microbes Infect 1: e7; doi:10.1038/emi.2012.3 LINK


Title: Global tuberculosis control: lessons learnt and future prospects

Authors: Lienhardt C, Glaziou P, Uplekar M, Lönnroth K, Getahun H, Raviglione M

Nat Rev Microbiol 2012 May 14;10(6):407-16. doi: 10.1038/nrmicro2797. LINK


2011

Title: The challenge of new drug discovery for tuberculosis

Authors: Koul A, Arnoult E, Lounis N, Guillemont J, Andries K

Nature 2011 Jan 27;469(7331):483-90. doi: 10.1038/nature09657. LINK


Title: Towards a point-of-care test for active tuberculosis: obstacles and opportunities

Authors: McNerney R, Daley P

Nat Rev Microbiol 2011 Mar;9(3):204-13. doi: 10.1038/nrmicro2521. LINK


Title: The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ

Authors: Ma F, Xu S, Liu X, Zhang Q, Xu X, Liu M, Hua M, Li N, Yao H, Cao X

Nat Immunol 2011 Jul 24;12(9):861-9. doi: 10.1038/ni.2073. LINK


Title: A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

Authors: Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, Porcelli SA, Jacobs WR Jr

Nat Med 2011 Sep 4;17(10):1261-8. doi: 10.1038/nm.2420. LINK

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